Dressings Loaded with Cyclodextrin-Hamamelitannin Complexes Increase Staphylococcus aureus Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities

被引：61

作者：

Brackman, Gilles ^{[1
]}

Jose Garcia-Fernandez, Maria ^{[2
]}

Lenoir, Joke ^{[3
]}

De Meyer, Laurens ^{[4
]}

Remon, Jean-Paul ^{[3
]}

De Beer, Thomas ^{[4
]}

Concheiro, Angel ^{[2
]}

Alvarez-Lorenzo, Carmen ^{[2
]}

Coenye, Tom ^{[1
]}

机构：

[1] Univ Ghent, Fac Pharmaceut Sci, Lab Pharmaceut Microbiol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium

[2] Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15782, Spain

[3] Univ Ghent, Lab Pharmaceut Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium

[4] Univ Ghent, Lab Pharmaceut Proc Analyt Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium

来源：

MACROMOLECULAR BIOSCIENCE | 2016年 / 16卷 / 06期

关键词：

cellulose; cyclodextrins; drug delivery systems; hamamelitannin; quorum sensing; QUORUM-SENSING INHIBITORS; IN-VITRO; PSEUDOMONAS-AERUGINOSA; BETA-CYCLODEXTRIN; BACTERIA; WOUNDS; ATTENUATION; INFECTIONS; VANCOMYCIN; INSIGHTS;

D O I：

10.1002/mabi.201500437

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Bacteria reside within biofilms at the infection site, making them extremely difficult to eradicate with conventional wound care products. Bacteria use quorum sensing (QS)systems to regulate biofilm formation, and QS inhibitors (QSIs) have been proposed as promising antibiofilm agents. Despite this, few antimicrobial therapies that interfere with QS exist. Nontoxic hydroxypropyl-beta-cyclodextrin-functionalized cellulose gauzes releasing a burst of the antibiotic vancomycin and the QSI hamamelitannin are developed, followed by a sustained release of both. The gauzes affect QS and biofilm formation of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro model of chronic wound infection and can be considered as candidates to be used to prevent wound infection as well as treat infected wounds.

引用

页码：859 / 869

页数：11

共 53 条

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