Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder

被引：5

作者：

Bryant, Richard A. ^{[1
,2
]}

Felmingham, Kim ^{[1
,2
]}

Whitford, Thomas J. ^{[2
]}

Kemp, Andrew ^{[2
]}

Hughes, Gerard ^{[3
]}

Peduto, Anthony ^{[3
]}

Williams, Leanne M. ^{[2
]}

机构：

[1] Univ New S Wales, Sch Psychol, Sydney, NSW 2052, Australia

[2] Westmead Hosp, Brain Dynam Ctr, Sydney, NSW, Australia

[3] Westmead Hosp, Dept Radiol, Sydney, NSW, Australia

来源：

JOURNAL OF PSYCHIATRY & NEUROSCIENCE | 2008年 / 33卷 / 02期

关键词：

stress disorders; post-traumatic; magnetic resonance imaging; cognitive therapy;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: To index the extent to which treatment response in posttraumatic stress disorder ( PTSD) is predicted by rostral anterior cingulate cortex (rACC) volume. Method: We used structural magnetic resonance imaging in a 1.5 T scanner to examine subjects with PTSD (n= 13), traumatized control subjects ( n= 13) and nontraumatized control subjects ( n= 13). Subjects with PTSD then participated in 8 sessions of cognitive-behavioural therapy, after which we reassessed them for PTSD. Results: According to voxel-based morphometry, treatment responders had larger rACC volume than nonresponders. Further, symptom reduction was associated with larger rACC volume. Conclusion: Consistent with evidence for the neural bases of extinction learning, PTSD patients with larger rACC volume may be better able to regulate fear during cognitive-behavioural therapy and thus achieve greater treatment gains.

引用

页码：142 / 146

页数：5

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