Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients

被引：32

作者：

Weber-Hamann, B

Kopf, D

Lederbogen, F

Gilles, M

Heuser, I

Colla, M

Deuschle, M

机构：

[1] Cent Inst Mental Hlth, DE-68159 Mannheim, Germany

[2] Charite, Dept Psychiat, Berlin, Germany

来源：

NEUROENDOCRINOLOGY | 2005年 / 81卷 / 03期

关键词：

glucose tolerance; adrenal steroids; insulin; insulin receptors; corticotropin; clinical neuroendocrinology; depression;

D O I：

10.1159/000087003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We hypothesized that the activity of the hypothalamuspituitary-adrenal system in depressed patients is related to oral glucose tolerance. In 70 moderately depressed inpatients, we measured morning saliva cortisol for 6 days and assessed oral glucose tolerance. We found glucose concentrations to be positively associated with mean morning cortisol concentrations (F-3,F-236 = 2.86, p < 0.05). Also, the ISI, a measure of insulin receptor sensitivity, was negatively associated with mean morning cortisol concentrations ( r = - 0.25, p < 0.04). These findings support the hypothesis that hypercortisolemia may lead to disturbed glucose utilization in depressed patients. Copyright (C) 2005 S. Karger AG, Basel.

引用

收藏

页码：200 / 204

页数：5

相关论文

共 31 条

[1]

ANDERSON RJ, 2001, DIABETES CARE, V21, P296

[2] Effects of the 11β-hydroxysteroid dehydrogrenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes [J].

Andrews, RC ;

Rooyackers, O ;

Walker, BR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :285-291

[3]

Bjorntorp P, 1996, INT J OBESITY, V20, P291

[4] INSULIN RELEASE AND PERIPHERAL SENSITIVITY AT THE ORAL GLUCOSE-TOLERANCE TEST [J].

CEDERHOLM, J ;

WIBELL, L .

DIABETES RESEARCH AND CLINICAL PRACTICE, 1990, 10 (02) :167-175

[5] The relationship of depressive symptoms to symptom reporting, self-care and glucose control in diabetes [J].

Ciechanowski, PS ;

Katon, WJ ;

Russo, JE ;

Hirsch, IB .

GENERAL HOSPITAL PSYCHIATRY, 2003, 25 (04) :246-252

[6] Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure [J].

Colao, A ;

Pivonello, R ;

Spiezia, S ;

Faggiano, A ;

Ferone, D ;

Filippella, M ;

Marzullo, P ;

Cerbone, G ;

Siciliani, M ;

Lombardi, G .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (08) :2664-2672

[7] FEAST AND FAMINE - CRITICAL ROLE OF GLUCOCORTICOIDS WITH INSULIN IN DAILY ENERGY-FLOW [J].

DALLMAN, MF ;

STRACK, AM ;

AKANA, SF ;

BRADBURY, MJ ;

HANSON, ES ;

SCRIBNER, KA ;

SMITH, M .

FRONTIERS IN NEUROENDOCRINOLOGY, 1993, 14 (04) :303-347

[8] Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls [J].

Deuschle, M ;

Schweiger, U ;

Weber, B ;

Gotthardt, U ;

Korner, A ;

Schmider, J ;

Stanhardt, E ;

Lammers, CH ;

Heuser, I .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (01) :234-238

[9] Antidepressive treatment with amitriptyline and paroxetine: Effects on saliva cortisol concentrations [J].

Deuschle, M ;

Hamann, B ;

Meichel, C ;

Krumm, B ;

Lederbogen, F ;

Kniest, A ;

Colla, M ;

Heuser, I .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2003, 23 (02) :201-205

[10] Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle [J].

Dimitriadis, G ;

Leighton, B ;

ParryBillings, M ;

Sasson, S ;

Young, M ;

Krause, U ;

Bevan, S ;

Piva, T ;

Wegener, G ;

Newsholme, EA .

BIOCHEMICAL JOURNAL, 1997, 321 :707-712

← 1 2 3 4 →