The epidermal growth factor receptor family

被引：180

作者：

Bazley, LA ^{[1
]}

Gullick, WJ ^{[1
]}

机构：

[1] Univ Kent, Canc Biol Lab, Res Sch Biosci, Canterbury CT2 7NJ, Kent, England

来源：

ENDOCRINE-RELATED CANCER | 2005年 / 12卷

关键词：

D O I：

10.1677/erc.1.01032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epidermal growth factor receptor family consists of four receptor genes and at least 11 ligands, several of which are produced in different protein forms. They create an interacting system that has the ability to receive and process information that results in multiple outputs. The family has an important role in directing and coordinating many normal processes, including growth and development, normal tissue turnover and wound healing. Its members are also aberrantly activated by overexpression or mutation in many common human tumour types and as such have been the target for anticancer drug development.

引用

页码：S17 / S27

页数：11

共 117 条

[1] Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors [J].

Alimandi, M ;

Wang, LM ;

Bottaro, D ;

Lee, CC ;

Kuo, A ;

Frankel, M ;

Fedi, P ;

Tang, C ;

Lippman, M ;

Pierce, JH .

EMBO JOURNAL, 1997, 16 (18) :5608-5617

[2] The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions [J].

Alroy, I ;

Yarden, Y .

FEBS LETTERS, 1997, 410 (01) :83-86

[3]

Bacus SS, 1996, ONCOGENE, V12, P2535

[4] CYCLIN D1 PROTEIN EXPRESSION AND FUNCTION IN HUMAN BREAST-CANCER [J].

BARTKOVA, J ;

LUKAS, J ;

MULLER, H ;

LUTZHOFT, D ;

STRAUSS, M ;

BARTEK, J .

INTERNATIONAL JOURNAL OF CANCER, 1994, 57 (03) :353-361

[5]

Baulida J, 1996, J BIOL CHEM, V271, P5251

[6] A SINGLE AUTOPHOSPHORYLATION SITE CONFERS ONCOGENICITY TO THE NEU/ERBB-2 RECEPTOR AND ENABLES COUPLING TO THE MAP KINASE PATHWAY [J].

BENLEVY, R ;

PATERSON, HF ;

MARSHALL, CJ ;

YARDEN, Y .

EMBO JOURNAL, 1994, 13 (14) :3302-3311

[7]

BENLEVY R, 1992, J BIOL CHEM, V267, P17304

[8] CORRELATION OF THE STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THE NEU ONCOGENE-ENCODED P185 PROTEIN WITH ITS FUNCTION [J].

BRANDTRAUF, PW ;

RACKOVSKY, S ;

PINCUS, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) :8660-8664

[9] CONFORMATION OF THE TRANSMEMBRANE DOMAIN OF THE C-ERBB-2 ONCOGENE-ENCODED PROTEIN IN ITS MONOMERIC AND DIMERIC STATES [J].

BRANDTRAUF, PW ;

PINCUS, MR ;

MONACO, R .

JOURNAL OF PROTEIN CHEMISTRY, 1995, 14 (01) :33-40

[10] Neuregulins and their receptors: A versatile signaling module in organogenesis and oncogenesis [J].

Burden, S ;

Yarden, Y .

NEURON, 1997, 18 (06) :847-855

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