Neonatal glucocorticoids and the developing brain: short-term treatment with life-long consequences?

被引:56
作者
Bakker, JM
van Bel, F
Heijnen, CJ
机构
[1] Univ Utrecht, Wilhelmina Childrens Hosp, Med Ctr, Dept Neonatol, NL-3584 EA Utrecht, Netherlands
[2] Univ Utrecht, Wilhelmina Childrens Hosp, Med Ctr, Dept Immunol, NL-3584 EA Utrecht, Netherlands
关键词
D O I
10.1016/S0166-2236(00)01948-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although synthetic glucocorticoids are frequently used in hospital for the prevention of chronic lung disease in premature infants, major concern has arisen about the possible long-term consequences of these treatments. Animal research provides evidence for the idea that neonatal glucocorticoid treatment enhances susceptibility to autoimmune disease in adult life. Altered functioning of the hypothalamo-pituitary-adrenal axis, and/or changes at higher brain levels might underlie alterations in disease susceptibility.
引用
收藏
页码:649 / 653
页数:5
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