Ambulatory blood pressure, blood pressure variability and the prevalence of carotid artery alteration: the Ohasama study

被引:77
作者
Shintani, Yoriko
Kikuya, Masahiro
Hara, Azusa
Ohkubo, Takayoshi
Metoki, Hirohito
Asayama, Kei
Inoue, Ryusuke
Obara, Taku
Aono, Yoko
Hashimoto, Takanao
Hashimoto, Junichiro
Totsune, Kazuhito
Hoshi, Haruhisa
Satoh, Hiroshi
Imai, Yutaka
机构
[1] Tohoku Univ, Dept Clin Pharmacol & Therapeut, Grad Sch Pharmaceut Sci & Med, Sendai, Miyagi 980, Japan
[2] Tohoku Univ, Dept Planning Drug Dev & Clin Evaluat, Grad Sch Pharmaceut Sci & Med, Sendai, Miyagi 980, Japan
[3] Tohoku Univ, Dept Environm Hlth Sci, Grad Sch Pharmaceut Sci & Med, Sendai, Miyagi 980, Japan
[4] Ohasama Hosp, Iwate, Japan
[5] Tohoku Univ, 21st Century COE Program, Comprehens Res & Educ Ctr Planning Drug Dev & Cli, Sendai, Miyagi 980, Japan
关键词
ambulatory blood pressure; blood pressure variability; carotid atherosclerosis; general population; night-time blood pressure; INTIMA-MEDIA THICKNESS; BASE-LINE DATA; PROGNOSTIC-SIGNIFICANCE; GENERAL-POPULATION; MYOCARDIAL-INFARCTION; EUROPEAN LACIDIPINE; NOCTURNAL FALL; ATHEROSCLEROSIS; RISK; STROKE;
D O I
10.1097/HJH.0b013e328172dc2e
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objectives To investigate the association between ambulatory blood pressure (BP) variables (level, short-term variability, circadian variation and morning pressor surge) and carotid artery alteration in a general population. Methods We measured ambulatory BP every 30 min in 775 participants (mean age 66.2 +/- 6.2 years, 68.8% women) from the Japanese general population. Short-term BID variability during the daytime and night-time were estimated as within-subject standard deviation of daytime and night-time BP, respectively. Circadian BP variation was calculated as the percentage decline in nocturnal BP. Morning pressor surge was defined as morning BP minus pre-waking BP. The extent of carotid artery alteration was evaluated as the average of common carotid intima-media thickness (IMT) and the presence of focal carotid plaque. Results Daytime and night-time BP values were more closely associated with carotid artery alteration than casual BP. With mutual adjustment for daytime and night-time BP, the latter (P < 0.0001) was more closely associated with IMT, which represents diffuse arterial thickening and arteriosclerosis, than daytime BP (P = 0.2). Night-time systolic BP variability was positively associated with carotid plaque (focal atherosclerotic lesions) independently of possible confounding factors, including night-time systolic BP (P = 0.01). A diminished nocturnal decline in systolic BP was associated with a greater IMT after adjustment for confounding factors (P = 0.03). A morning pressor surge was not associated with carotid artery alteration. Conclusion Ambulatory BP levels and BP variability were closely associated with carotid artery alteration, suggesting that these parameters are independent risk factors or predictors of carotid artery alteration.
引用
收藏
页码:1704 / 1710
页数:7
相关论文
共 40 条
  • [1] Association for the Advancement of Medical Instrumentation (AAMI), 1987, AM NAT STAND EL AUT
  • [2] Relation of intima-media thickness to atherosclerotic plaques in carotid arteries - The vascular aging (EVA) study
    BonithonKopp, C
    Touboul, PJ
    Berr, C
    Leroux, C
    Mainard, F
    Courbon, D
    Ducimetiere, P
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1996, 16 (02) : 310 - 316
  • [3] Common carotid intima-media thickness and risk of stroke and myocardial infarction - The Rotterdam Study
    Bots, ML
    Hoes, AW
    Koudstaal, PJ
    Hofman, A
    Grobbee, DE
    [J]. CIRCULATION, 1997, 96 (05) : 1432 - 1437
  • [4] Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium
    Chappell, DC
    Varner, SE
    Nerem, RM
    Medford, RM
    Alexander, RW
    [J]. CIRCULATION RESEARCH, 1998, 82 (05) : 532 - 539
  • [5] Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Chobanian, AV
    Bakris, GL
    Black, HR
    Cushman, WC
    Green, LA
    Izzo, JL
    Jones, DW
    Materson, BJ
    Oparil, S
    Wright, JT
    Roccella, EJ
    [J]. HYPERTENSION, 2003, 42 (06) : 1206 - 1252
  • [6] Cardiovascular target organ damage in essential hypertensives with or without reproducible nocturnal fall in blood pressure
    Cuspidi, C
    Meani, S
    Salerno, M
    Valerio, C
    Fusi, V
    Severgnini, B
    Lonati, L
    Magrini, F
    Zanchetti, A
    [J]. JOURNAL OF HYPERTENSION, 2004, 22 (02) : 273 - 280
  • [7] CONTINUOUS VS INTERMITTENT BLOOD-PRESSURE MEASUREMENTS IN ESTIMATING 24-HOUR AVERAGE BLOOD-PRESSURE
    DIRIENZO, M
    GRASSI, G
    PEDOTTI, A
    MANCIA, G
    [J]. HYPERTENSION, 1983, 5 (02) : 264 - 269
  • [8] THE RELATIONSHIPS BETWEEN LEFT-VENTRICULAR MASS AND DAYTIME AND NIGHTTIME BLOOD PRESSURES - A METAANALYSIS OF COMPARATIVE-STUDIES
    FAGARD, R
    STAESSEN, JA
    THIJS, L
    [J]. JOURNAL OF HYPERTENSION, 1995, 13 (08) : 823 - 829
  • [9] Detection of carotid atherosclerosis in individuals with masked hypertension and white-coat hypertension by self-measured blood pressure at home: The Ohasama Study
    Hara, Azusa
    Ohkubo, Takayoshi
    Kikuya, Masahiro
    Shintani, Yoriko
    Obara, Taku
    Metoki, Hirohito
    Inoue, Ryusuke
    Asayama, Kei
    Hashimoto, Takanao
    Harasawa, Toshiya
    Aono, Yoko
    Otani, Harunori
    Tanaka, Kazushi
    Hashimoto, Junichiro
    Totsune, Kazuhito
    Hoshi, Haruhisa
    Satoh, Hiroshi
    Imai, Yutaka
    [J]. JOURNAL OF HYPERTENSION, 2007, 25 (02) : 321 - 327
  • [10] Hata Yoshiya, 2002, J Atheroscler Thromb, V9, P1