Heat shock protein hsp70 overexpression confers resistance against nitric oxide

被引:154
作者
Bellmann, K [1 ]
Jaattela, M [1 ]
Wissing, D [1 ]
Burkart, V [1 ]
Kolb, H [1 ]
机构
[1] DANISH CANC SOC RES CTR,DIV CANC BIOL,DEPT TUMOR CELL BIOL,DK-2100 COPENHAGEN,DENMARK
关键词
diabetes; Hsp70; nitric oxide; RIN cell;
D O I
10.1016/0014-5793(96)00730-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Heat stress is known to render rat islet cells resistant against the toxic effects of nitric oxide, reactive oxygen intermediates and the islet cell toxin streptozotocin, We report here for the first time that protection against nitric oxide is mediated by the major heat shock protein, hsp70, even in the absence of heat stress, The human hsp70 gene was stably transfected into the rat insulinoma cell line RINm5F, Constitutive expression of hsp70 caused protection from NO-induced cell lysis which was of the same extent as seen after heat stressing cells, Our results identify hsp70 as a defence molecule against nitric oxide.
引用
收藏
页码:185 / 188
页数:4
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