The mycobacteria story in Crohn's disease

被引:50
作者
Shanahan, F [1 ]
O'Mahony, J [1 ]
机构
[1] Natl Univ Ireland Univ Coll Cork, Dept Med, Alimentary Pharmabiot Ctr, Cork, Ireland
关键词
D O I
10.1111/j.1572-0241.2005.50358.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The heterogeneity of Crohn's disease suggests that it would be unwise to dismiss an infectious contribution to the pathogenesis in a subset of patients. The most enduring infectious candidate has been Mycobacterium paratuberculosis, which appears to be widespread in nature and appears to have the potential to infect humans. However, there are many counterarguments to the notion that MAP causes Crohn's disease, and numerous observations are seemingly at variance with this concept.
引用
收藏
页码:1537 / 1538
页数:2
相关论文
共 19 条
[1]  
[Anonymous], REV EVIDENCE LINK EX
[2]   Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases [J].
Bach, JF .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :911-920
[3]   Johne's disease, inflammatory bowel disease, and Mycobacterium paratuberculosis [J].
Chacon, O ;
Bermudez, LE ;
Barletta, RG .
ANNUAL REVIEW OF MICROBIOLOGY, 2004, 58 :329-363
[4]   High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease [J].
Darfeuille-Michaud, A ;
Boudeau, J ;
Bulois, P ;
Neut, C ;
Glasser, AL ;
Barnich, N ;
Bringer, MA ;
Swidsinski, A ;
Beaugerie, L ;
Colombel, JF .
GASTROENTEROLOGY, 2004, 127 (02) :412-421
[5]  
Ekbom A, 2003, INFLAMM BOWEL DIS, P5
[6]  
*EUR COMM, POSS LINKS CROHNS DI
[7]  
GOULD G, 2004, ILSI EUROPE REPORT S
[8]   Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease [J].
Greenstein, RJ .
LANCET INFECTIOUS DISEASES, 2003, 3 (08) :507-514
[9]   A Toll-like receptor recognizes bacterial DNA [J].
Hemmi, H ;
Takeuchi, O ;
Kawai, T ;
Kaisho, T ;
Sato, S ;
Sanjo, H ;
Matsumoto, M ;
Hoshino, K ;
Wagner, H ;
Takeda, K ;
Akira, S .
NATURE, 2000, 408 (6813) :740-745
[10]   Grand round -: Mycobacterium paratuberculosis cervical lymphadenitis, followed five years later by terminal ileitis similar to Crohn's disease [J].
Hermon-Taylor, J ;
Barnes, N ;
Clarke, C ;
Finlayson, C .
BRITISH MEDICAL JOURNAL, 1998, 316 (7129) :449-453