Respiratory symptoms and cotton dust exposure; results of a 15 year follow up observation

被引:55
作者
Wang, XR
Eisen, EA
Zhang, HX
Sun, BX
Dai, HL
Pan, LD
Wegman, DH
Olenchock, SA
Christiani, DC
机构
[1] Harvard Univ, Sch Publ Hlth, Occupat Hlth Program, Dept Environm Hlth, Boston, MA 02115 USA
[2] Shanghai Text Bur, Hosp 1, Shanghai, Peoples R China
[3] Univ Massachusetts, Dept Work Environm, Lowell, MA USA
[4] NIOSH, Morgantown, WV USA
[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Pulm & Crit Care Unit, Boston, MA USA
关键词
D O I
10.1136/oem.60.12.935
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Aims: To determine chronic effects of long term exposure to cotton dust and endotoxin on incidence of respiratory symptoms and the effect of cessation of exposure. Methods: Respiratory health in 429 Chinese cotton textile workers ( study group) and 449 silk textile workers ( control group) was followed prospectively from 1981 to 1996. Byssinosis, chest tightness, and non-specific respiratory symptoms were assessed by means of identical standardised questionnaires at four time points. Exposures to cotton dust and endotoxin were estimated using area samples collected at each survey. Incidence and persistence of symptoms were examined in relation to cumulative exposure and exposure cessation using generalised estimating equations (GEE). Results: Among cotton workers, the cumulative incidence of byssinosis and chest tightness was 24% and 23%, respectively, and was significantly more common in smokers than in non-smokers. A high proportion of symptoms was found to be intermittent, rather than persistent. Among silk workers, no typical byssinosis was identified; the incidence of chest tightness was 10%. Chronic bronchitis, cough, and dyspnoea were more common and persistent in the cotton group than in the silk group. Significantly lower odds ratios for symptoms were observed in cotton workers who left the cotton mills; risk was also related to years since last worked. Multivariate analysis indicated a trend for higher cumulative exposure to endotoxin in relation to a higher risk for byssinosis. Conclusion: Chronic exposure to cotton dust is related to both work specific and non-specific respiratory symptoms. Byssinosis is more strongly associated with exposure to endotoxin than to dust. Cessation of exposure may improve the respiratory health of cotton textile workers; the improvement appears to increase with time since last exposure.
引用
收藏
页码:935 / 941
页数:7
相关论文
共 43 条
[1]  
BERRY G, 1974, BRIT J IND MED, V31, P18
[2]  
BERRY G, 1973, BRIT J IND MED, V30, P25
[3]   PRIORITIES IN PREVENTION OF CHRONIC LUNG-DISEASES [J].
BOUHUYS, A ;
BECK, GJ ;
SCHOENBERG, JB .
LUNG, 1979, 156 (02) :129-148
[4]  
BOUHUYS A, 1977, LUNG, V154, P167
[5]   BYSSINOSIS IN COTTON TEXTILE WORKERS - RESPIRATORY SURVEY OF A MILL WITH RAPID LABOR TURNOVER [J].
BOUHUYS, A ;
WOLFSON, RL ;
HORNER, DW ;
BRAIN, JD ;
ZUSKIN, E .
ANNALS OF INTERNAL MEDICINE, 1969, 71 (02) :257-+
[6]   INHALED ENDOTOXIN AND DECREASED SPIROMETRIC VALUES - AN EXPOSURE RESPONSE RELATION FOR COTTON DUST [J].
CASTELLAN, RM ;
OLENCHOCK, SA ;
KINSLEY, KB ;
HANKINSON, JL .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (10) :605-610
[7]  
Christiani DC, 1999, AM J IND MED, V35, P321, DOI 10.1002/(SICI)1097-0274(199904)35:4<321::AID-AJIM1>3.0.CO
[8]  
2-L
[9]   COTTON DUST EXPOSURE, ACROSS-SHIFT DROP IN FEV(1), AND 5-YEAR CHANGE IN LUNG-FUNCTION [J].
CHRISTIANI, DC ;
YE, TT ;
WEGMAN, DH ;
EISEN, EA ;
DAI, HL ;
LU, PL .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 150 (05) :1250-1255
[10]   RESPIRATORY-DISEASE IN COTTON TEXTILE WORKERS IN THE PEOPLES-REPUBLIC-OF-CHINA .1. RESPIRATORY SYMPTOMS [J].
CHRISTIANI, DC ;
EISEN, EA ;
WEGMAN, DH ;
YE, TT ;
LU, PL ;
GONG, ZC ;
DAI, HL .
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1986, 12 (01) :40-45