The aneuploidy paradox: costs and benefits of an incorrect karyotype

被引：177

作者：

Sheltzer, Jason M.

Amon, Angelika ^{[1
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

来源：

TRENDS IN GENETICS | 2011年 / 27卷 / 11期

关键词：

AUTOSOMAL DOSAGE COMPENSATION; HIGH MUTATION-RATES; C-MYC LOCUS; SACCHAROMYCES-CEREVISIAE; CHROMOSOME INSTABILITY; GENE-EXPRESSION; ADAPTIVE EVOLUTION; DOWNS-SYNDROME; CANCER-CELLS; LIFE-SPAN;

D O I：

10.1016/j.tig.2011.07.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date, aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also a hallmark of cancer, a disease of enhanced proliferative capacity, and aneuploid cells are frequently recovered following the experimental evolution of microorganisms. Thus, in certain contexts, aneuploidy might also have growth-advantageous properties. New models of aneuploidy and chromosomal instability have shed light on the diverse effects that karyotypic imbalances have on cellular phenotypes, and suggest novel ways of understanding the role of aneuploidy in development and disease.

引用

收藏

页码：446 / 453

页数：8

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