Controlled release of glucose through modified chitosan membranes

被引：52

作者：

Singh, DK

Ray, AR ^{[1
]}

机构：

[1] Indian Inst Technol, Ctr Biomed Engn, New Delhi 110016, India

[2] All India Inst Med Sci, New Delhi 110016, India

来源：

JOURNAL OF MEMBRANE SCIENCE | 1999年 / 155卷 / 01期

关键词：

chitosan; graft copolymerization; permeability; glucose; controlled release;

D O I：

10.1016/S0376-7388(98)00311-1

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Controlled release of glucose as a model compound through modified chitosan membranes was studied. The chitosan membranes were modified by graft copolymerization of 2-hydroxyethylmethacrylate (HEMA) onto chitosan films using Co-60 gamma-ray irradiation. The release characteristics of glucose were studied as a function of degree of grafting. The permeability coefficient of glucose through grafted membranes was found to be in the order 10(-6)-10(-7) cm(2)/s. The effect of thickness of membranes on the permeability was also determined. Chitosan membranes showed a negligible boundary layer effect. The release of,glucose was found to be pH dependent. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：107 / 112

页数：6

共 15 条

[1] CHITOSAN - AS A BIOMATERIAL [J].