Apoptosis in neurodegenerative diseases: the role of mitochondria

被引:223
作者
Tatton, WG [1 ]
Olanow, CW [1 ]
机构
[1] CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1999年 / 1410卷 / 02期
关键词
apoptosis; mitochondrion; neurodegenerative disease; permeability transition pore;
D O I
10.1016/S0005-2728(98)00167-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nerve cell death is the central feature of the human neurodegenerative diseases. It has long been thought that nerve cell death in these disorders occurs by way of necrosis, a process characterized by massive transmembrane ion currents, compromise of mitochondrial ATP production, and the formation of high levels of reactive oxygen species combining to induce rapid disruption of organelles, cell swelling, and plasma membrane rupture with a secondary inflammatory response. Nuclear DNA is relatively preserved. Recent evidence now indicates that the process of apoptosis rather than necrosis primarily contributes to nerve cell death in neurodegeneration. This has opened up new avenues for understanding the pathogenesis of neurodegeneration and may lead to new and more effective therapeutic approaches to these diseases. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:195 / 213
页数:19
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