The pathophysiology of long-term neuromuscular and cognitive outcomes following critical illness

被引：32

作者：

Herridge, Margaret S. ^{[1
]}

Batt, Jane ^{[2
]}

Hopkins, Ramona O. ^{[3
,4
]}

机构：

[1] Univ Toronto, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada

[2] Univ Toronto, St Michaels Hosp, Toronto, ON M5B 1W8, Canada

[3] Latter Day St Hosp, Dept Med, Pulm & Crit Care Div, Salt Lake City, UT 84143 USA

[4] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA

来源：

CRITICAL CARE CLINICS | 2008年 / 24卷 / 01期

关键词：

D O I：

10.1016/j.ccc.2007.11.002

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Despite the recent and marked improvement in short-term mortality after critical illness, significant morbidities persist for many patients following hospital discharge. This article discusses the risk factors for muscle, nerve, and brain dysfunction after critical illness and preliminary basic science data to support possible pathophysiologic mechanisms mediating this disability. Additionally, it presents a roadmap outlining future directions in this area of research.

引用

页码：179 / +

页数：22

共 163 条

[1] Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations [J].

Aljada, A ;

Ghanim, H ;

Mohanty, P ;

Kapur, N ;

Dandona, P .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (03) :1419-1422

[2] Critical illness myopathy: Further evidence from muscle-fiber excitability studies of an acquired channelopathy [J].

Allen, David C. ;

Arunachalam, Ramamurthy ;

Mills, Kerry R. .

MUSCLE & NERVE, 2008, 37 (01) :14-22

[3]

ALSAIDI F, 2003, AM J RESP CRIT CARE, V167, pA737

[4] Exposure to anaesthetic agents, cognitive functioning and depressive symptomatology in the elderly [J].

Ancelin, ML ;

De Roquefeuil, G ;

Ledésert, B ;

Bonnel, F ;

Cheminal, JC ;

Ritchie, K .

BRITISH JOURNAL OF PSYCHIATRY, 2001, 178 :360-366

[5] Quality-adjusted survival in the first year after the acute respiratory distress syndrome [J].

Angus, DC ;

Musthafa, AA ;

Clermont, G ;

Griffin, MF ;

Linde-Zwirble, WT ;

Dremsizov, TT ;

Pinsky, MR .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (06) :1389-1394

[6] Surviving intensive care: a report from the 2002 Brussels Roundtable [J].

Angus, DC ;

Carlet, J .

INTENSIVE CARE MEDICINE, 2003, 29 (03) :368-377

[7] Brain injury and inflammation - A putative role of TNF alpha [J].

Arvin, B ;

Neville, LF ;

Barone, FC ;

Feuerstein, GZ .

NEUROPROTECTIVE AGENTS: CLINICAL AND EXPERIMENTAL ASPECTS, 1995, 765 :62-71

[8]

Arvin B., 1995, ANN NY ACAD SCI, V765, P98

[9]

Bal-Price A, 2001, J NEUROSCI, V21, P6480

[10] Cognitive impairment in sepsis survivors from cecal ligation and perforation [J].

Barichello, T ;

Martins, WR ;

Reinke, A ;

Feier, G ;

Rifter, C ;

Quevedo, J ;

Dal-Pizzol, F .

CRITICAL CARE MEDICINE, 2005, 33 (01) :221-223

← 1 2 3 4 5 6 7 8 9 10 →