Isolation and characterization of a Vibrio vulnificus mutant deficient in both extracellular metalloprotease and cytolysin

被引：72

作者：

Fan, JJ ^{[1
]}

Shao, CP ^{[1
]}

Ho, YC ^{[1
]}

Yu, CK ^{[1
]}

Hor, LI ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Dept Microbiol & Immunol, Coll Med, Tainan 701, Taiwan

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 09期

关键词：

D O I：

10.1128/IAI.69.9.5943-5948.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We isolated a Vibrio vulnificus mutant that was deficient in both metalloprotease and cytolysin by allelic exchange. The virulence of this mutant in mice and its cytotoxicity for HEp-2 cells were comparable to those of the wild-type strain, indicating that neither factor was essential for these properties. The cytolysin, but not the protease, seemed to be important for causing damage in the alimentary tract of the mice.

引用

页码：5943 / 5948

页数：6

共 36 条

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