Analysis of LHX8 mutation in premature ovarian failure

被引：37

作者：

Qin, Yingying ^{[1
,2
]}

Zhao, Han ^{[1
,2
]}

Kovanci, Ertug ^{[1
]}

Simpson, Joe Leigh ^{[3
,4
]}

Chen, Zi-Jiang ^{[2
]}

Rajkovic, Aleksandar ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA

[2] Shandong Univ, Ctr Reprod Med, Shandong Prov Hosp, Jinan 250100, Peoples R China

[3] Florida Int Univ, Coll Med, Dept Human & Mol Genet, Miami, FL 33199 USA

[4] Florida Int Univ, Coll Med, Dept Obstet & Gynecol, Miami, FL 33199 USA

来源：

FERTILITY AND STERILITY | 2008年 / 89卷 / 04期

关键词：

D O I：

10.1016/j.fertnstert.2007.04.017

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The LHX8 (LIM homeobox 8) gene encodes a LIM homeodomain transcriptional regulator that is preferentially expressed in germ cells and critical for mammalian oogenesis. The authors investigated whether nucleotide changes were present in the LHX8 gene of Caucasian women with premature ovarian failure (POF), as compared with control women. When the authors sequenced 95 Caucasian women with POF, they discovered two novel single-nucleotide polymorphisms (SNPs) in intron 3 (c.769+10G>T) and 3' untranslated region (c.1787A>G) of the LHX8 gene. These polymorphisms also were found in controls (n = 94), at frequencies that were not statistically different from. those in POF women. Mutations in the LHX8 exons are uncommon in Caucasian women with POF. (Fertil Steril (R) 2008;89:1012-4. (c) 2008 by American Society for Reproductive Medicine.)

引用

页码：1012 / 1014

页数：3

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