Solution and solid phase synthesis of 5-alkoxyhydantoin libraries with a three-fold functional diversity

被引:91
作者
Hanessian, S
Yang, RY
机构
[1] Department of Chemistry, Université de Montréal, Montreal, Que. H3C 3J7, C.P. 6128, Succ. Centre-ville
基金
加拿大自然科学与工程研究理事会;
关键词
D O I
10.1016/0040-4039(96)01244-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A general method for the synthesis of 5-alkoxyhydantoins in solution and on solid support is described. A library of fifty discrete 5-alkoxyhydantoins with three functional group variations was prepared. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:5835 / 5838
页数:4
相关论文
共 21 条
  • [1] REACTIONS OF UREAS WITH GLYOXYLIC-ACID AND METHYL GLYOXYLATE
    BENISHAI, D
    ALTMAN, J
    BERNSTEIN, Z
    [J]. TETRAHEDRON, 1977, 33 (10) : 1191 - 1196
  • [2] Combinatorial organic synthesis using Parke-Davis's DIVERSOMER method
    DeWitt, SH
    Czarnik, AW
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) : 114 - 122
  • [3] DIVERSOMERS - AN APPROACH TO NONPEPTIDE, NONOLIGOMERIC CHEMICAL DIVERSITY
    DEWITT, SH
    KIELY, JS
    STANKOVIC, CJ
    SCHROEDER, MC
    CODY, DMR
    PAVIA, MR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) : 6909 - 6913
  • [4] Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization cleavage step
    Dressman, BA
    Spangle, LA
    Kaldor, SW
    [J]. TETRAHEDRON LETTERS, 1996, 37 (07) : 937 - 940
  • [5] AN EFFICIENT SYNTHESIS OF N-HYDROXY-ALPHA-AMINO ACID-DERIVATIVES OF HIGH OPTICAL PURITY
    FEENSTRA, RW
    STOKKINGREEF, EHM
    NIVARD, RJF
    OTTENHEIJM, HCJ
    [J]. TETRAHEDRON LETTERS, 1987, 28 (11) : 1215 - 1218
  • [6] INTERCONVERSION OF (R) AND (S)-ALPHA-HYDROXY ESTERS - PRECURSORS OF (S) AND (R)-O-BENZYL-ALPHA-HYDROXYLAMINO ACID-ESTERS OF HIGH OPTICAL PURITY
    FEENSTRA, RW
    STOKKINGREEF, EHM
    NIVARD, RJF
    OTTENHEIJM, HCJ
    [J]. TETRAHEDRON, 1988, 44 (17) : 5583 - 5595
  • [7] FELDER ER, 1994, CHIMIA, V48, P531
  • [8] FELDER ER, 1996, ACC CHEM RES, V29
  • [9] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .1. BACKGROUND AND PEPTIDE COMBINATORIAL LIBRARIES
    GALLOP, MA
    BARRETT, RW
    DOWER, WJ
    FODOR, SPA
    GORDON, EM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (09) : 1233 - 1251
  • [10] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS
    GORDON, EM
    BARRETT, RW
    DOWER, WJ
    FODOR, SPA
    GALLOP, MA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) : 1385 - 1401