How the T cell receptor sees antigen - A structural view

被引：133

作者：

Garcia, KC ^{[1
]}

Adams, EJ

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Biol Struct, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

CELL | 2005年 / 122卷 / 03期

关键词：

D O I：

10.1016/j.cell.2005.07.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structures of many of the cell surface receptor-ligand complexes mediating the interactions between T cells and target cells have been determined in the past ten years. While snapshots of T cell receptors bound to their peptide-MHC ligands appear to have defined a general interaction or "docking" solution, many of the most fundamental structural questions in antigen re cognition lack detailed answers and thus pose exciting experimental challenges for the future.

引用

页码：333 / 336

页数：4

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