Development and validation of a method for the analysis of a pharmaceutical preparation by near-infrared diffuse reflectance spectroscopy

被引：33

作者：

Blanco, M ^{[1
]}

Coello, J ^{[1
]}

Eustaquio, A ^{[1
]}

Iturriaga, H ^{[1
]}

Maspoch, S ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Dept Quim, Unidad Quim Analit, E-08193 Barcelona, Spain

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1999年 / 88卷 / 05期

关键词：

D O I：

10.1021/js980338f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A near-infrared (NIR) spectroscopic method based on the use of a fiber optical probe for the analysis of a commercially available pharmaceutical preparation is proposed. The analyte is identified by comparison with a second-derivative spectral library, using the correlation coefficient as the discriminating parameter. Once a sample has been positively identified, the active principle is quantified with partial least-squares (PLS) calibration. The proposed method was validated for use as a control method; to this end, the selectivity of the identification process, and the repeatability, intermediate precision, accuracy, linearity, and robustness of the active principle quantitation, were assessed.

引用

页码：551 / 556

页数：6

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