The MICAL proteins and rab1: a possible link to the cytoskeleton?

被引：55

作者：

Fischer, J ^{[1
]}

Weide, T ^{[1
]}

Barnekow, A ^{[1
]}

机构：

[1] Univ Munster, Dept Expt Tumorbiol, D-48149 Munster, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 328卷 / 02期

关键词：

rab; GTPase; Golgi; ER; vesicle transport; MICAL; cytoskeleton;

D O I：

10.1016/j.bbrc.2004.12.182

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The small GTPase rab1 plays a role in vesicle trafficking between ER and the Golgi complex. Recently, MICAL-1 was identified as new rab1 interacting protein. In this study, we show an interaction between two additional members of the MICAL family and rab1 in a yeast two-hybrid approach and GST pulldown experiments. We present data about the previously uncharacterized MICAL-3 concerning tissue distribution, size, and cellular localization. Furthermore, we investigated the connection between MICAL proteins and the cytoskeleton. Using the microtubule depolymerizing drug nocodazole we detected a link between MICAL-1 and -3, and the microtubule cytoskeleton. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：415 / 423

页数：9

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