Structural insight into the antibiotic action of telithromycin against resistant mutants

被引：140

作者：

Berisio, R

Harms, J

Schluenzen, F

Zarivach, R

Hansen, HAS

Fucini, P

Yonath, A ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel

[2] Max Planck Inst Mol Genet, Berlin, Germany

[3] Max Planck Res Unit Ribosomal Struct, Hamburg, Germany

[4] CNR, Inst Biostruct & Bioimaging, Naples, Italy

来源：

JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 14期

关键词：

D O I：

10.1128/JB.185.14.4276-4279.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

引用

页码：4276 / 4279

页数：4

共 19 条

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