Toll-like receptors and their signaling mechanisms

被引：215

作者：

Akira, S ^{[1
]}

Sato, S ^{[1
]}

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Japan Sci & Technol Corp,ERATO, Suita, Osaka 5650871, Japan

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2003年 / 35卷 / 09期

关键词：

D O I：

10.1080/00365540310015683

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Toll-like receptors (TLRs) play a crucial role in the recognition of invading pathogens and the activation of subsequent immune responses against them. Individual TLRs recognize distinct pathogen-associated molecular patterns (PAMPs). The TLR family harbors an extracellular leucine-rich repeat (LRR) domain as well as a cytoplasmic domain that is homologous to that of interleukin-1 receptor (IL-1R). Upon stimulation, TLR recruits IL-1R-associated protein kinases via adaptor MyD88, and finally induces activation of nuclear factor-kappaB and mitogen-activated protein kinases. However, the response to TLR ligands varies, indicating the diversity of TLR signaling pathways. Besides MyD88, several novel adaptor molecules have recently been identified. Differential utilization of these adaptor molecules may provide the specificity in the TLR signaling. Characterization of each TLR signaling pathway will reveal the molecular mechanism of self-tolerance as well as cross-tolerance in response to a variety of PAMPs.

引用

页码：555 / 562

页数：8

共 37 条

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