Oscillatory Synchronization in Large-Scale Cortical Networks Predicts Perception

被引:457
作者
Hipp, Joerg F. [1 ]
Engel, Andreas K. [1 ]
Siegel, Markus [1 ,2 ,3 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, D-20246 Hamburg, Germany
[2] MIT, Picower Inst Learning & Memory, Cambridge, MA 02139 USA
[3] Univ Tubingen, Ctr Integrat Neurosci, D-72076 Tubingen, Germany
关键词
VISUAL-ATTENTION; TOP-DOWN; NEURONAL OSCILLATIONS; CORTEX; INTEGRATION; MODULATION; RESPONSES; COHERENCE; REFLECTS; DISCRIMINATION;
D O I
10.1016/j.neuron.2010.12.027
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Normal brain function requires the dynamic interaction of functionally specialized but widely distributed cortical regions. Long-range synchronization of oscillatory signals has been suggested to mediate these interactions within large-scale cortical networks, but direct evidence is sparse. Here we show that oscillatory synchronization is organized in such large-scale networks. We implemented an analysis approach that allows for imaging synchronized cortical networks and applied this technique to EEG recordings in humans. We identified two networks: beta-band synchronization (similar to 20 Hz) in a fronto-parieto-occipital network and gamma-band synchronization (similar to 80 Hz) in a centro-temporal network. Strong perceptual correlates support their functional relevance: the strength of synchronization within these networks predicted the subjects' percept of an ambiguous audiovisual stimulus as well as the integration of auditory and visual information. Our results provide evidence that oscillatory neuronal synchronization mediates neuronal communication within frequency-specific, large-scale cortical networks.
引用
收藏
页码:387 / 396
页数:10
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