Catalytic asymmetric hydrogenation of N-iminopyridinium ylides:: Expedient approach to enantioenriched substituted piperidine derivatives

被引：234

作者：

Legault, CY ^{[1
]}

Charette, AB ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 25期

关键词：

D O I：

10.1021/ja0525298

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed an efficient catalytic enantioselective hydrogenation of pyridine derivatives. Enhanced reactivity was possible by an optimization of the electronic properties of the catalyst through ligand modification. This methodology shows the particular reactivity of N-iminopyridinium ylides that provides access to substituted piperidines in good enantiomeric excesses. Copyright © 2005 American Chemical Society.

引用

页码：8966 / 8967

页数：2

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