The axonal transport of beta(III)-tubulin is altered in both branches of sensory axons after injury of the rat sciatic nerve

被引：5

作者：

Hoffman, PN

Luduena, RF

机构：

[1] JOHNS HOPKINS UNIV HOSP,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205

[2] UNIV TEXAS,HLTH SCI CTR,DEPT BIOCHEM,SAN ANTONIO,TX 78284

来源：

BRAIN RESEARCH | 1996年 / 708卷 / 1-2期

关键词：

axon regeneration; axonal transport; cytoskeleton; axotomy; beta-tubulin; sensory neuron; dorsal root; sciatic nerve;

D O I：

10.1016/0006-8993(95)01433-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have analyzed the axonal transport of beta(III)-tubulin in the central (dorsal root) and peripheral (sciatic nerve) branches of sensory axons after injury of the sciatic nerve. Our finding that the relative amount of beta(III)-tubulin transported in slow component b (SCb) is increased in both axonal branches does not support the generally accepted hypothesis that the transport of cytoskeletal proteins is altered in the peripheral, but not the central branch after injury of the sciatic nerve.

引用

页码：182 / 184

页数：3

共 11 条

[1]

Brodal A., 1981, NEUROLOGICAL ANATOMY, DOI DOI 10.1002/ANA.410100629

[2] SLOW COMPONENT OF AXONAL-TRANSPORT - IDENTIFICATION OF MAJOR STRUCTURAL POLYPEPTIDES OF AXON AND THEIR GENERALITY AMONG MAMMALIAN NEURONS [J].