PGC-1 Coactivators in Cardiac Development and Disease

被引：316

作者：

Rowe, Glenn C.

Jiang, Aihua

Arany, Zolt

机构：

[1] Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

CIRCULATION RESEARCH | 2010年 / 107卷 / 07期

关键词：

PGC-1; metabolism; heart failure; mitochondria; PROLIFERATOR-ACTIVATED-RECEPTOR; FATTY-ACID OXIDATION; MITOCHONDRIAL TRANSCRIPTION FACTOR; ADENINE-NUCLEOTIDE TRANSLOCATOR; LEFT-VENTRICULAR HYPERTROPHY; NUCLEAR RESPIRATORY FACTORS; INCREASED GLUCOSE-OXIDATION; A DEHYDROGENASE-DEFICIENCY; ALPHA PPAR-ALPHA; NF-KAPPA-B;

D O I：

10.1161/CIRCRESAHA.110.223818

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The beating heart requires a constant flux of ATP to maintain contractile function, and there is increasing evidence that energetic defects contribute to the development of heart failure. The last 10 years have seen a resurgent interest in cardiac intermediary metabolism and a dramatic increase in our understanding of transcriptional networks that regulate cardiac energetics. The PPAR-gamma coactivator (PGC)-1 family of proteins plays a central role in these pathways. The mechanisms by which PGC-1 proteins regulate transcriptional networks and are regulated by physiological cues, as well as the roles they play in cardiac development and disease, are reviewed here. (Circ Res. 2010;107:825-838.)

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页码：825 / 838

页数：14

相关论文

共 193 条

[1] Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice [J].

Ahuja, Preeti ;

Zhao, Peng ;

Angelis, Ekaterini ;

Ruan, Hongmei ;

Korge, Paavo ;

Olson, Aaron ;

Wang, Yibin ;

Jin, Eunsook S. ;

Jeffrey, F. Mark ;

Portman, Michael ;

MacLellan, W. Robb .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (05) :1494-1505

[2] ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart [J].

Alaynick, William A. ;

Kondo, Richard P. ;

Xie, Wen ;

He, Weimin ;

Dufour, Catherine R. ;

Downes, Michael ;

Jonker, Johan W. ;

Giles, Wayne ;

Naviaux, Robert K. ;

Giguere, Vincent ;

Evans, Ronald M. .

CELL METABOLISM, 2007, 6 (01) :13-24

[3] ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis [J].

Alaynick, William A. ;

Way, James M. ;

Wilson, Stephanie A. ;

Benson, William G. ;

Pei, Liming ;

Downes, Michael ;

Yu, Ruth ;

Jonker, Johan W. ;

Holt, Jason A. ;

Rajpal, Deepak K. ;

Li, Hao ;

Stuart, Joan ;

McPherson, Ruth ;

Remlinger, Katja S. ;

Chang, Ching-Yi ;

McDonnell, Donald P. ;

Evans, Ronald M. ;

Billin, Andrew N. .

MOLECULAR ENDOCRINOLOGY, 2010, 24 (02) :299-309

[4] PGC-l-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells [J].

Andersson, U ;

Scarpulla, RC .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (11) :3738-3749

[5] A missense mutation in the mitochondrial cytochrome b gene in a revisited case with histiocytoid cardiomyopathy [J].

Andreu, AL ;

Checcarelli, N ;

Iwata, S ;

Shanske, S ;

DiMauro, S .

PEDIATRIC RESEARCH, 2000, 48 (03) :311-314

[6] Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy [J].

Antonicka, H ;

Mattman, A ;

Carlson, CG ;

Glerum, DM ;

Hoffbuhr, KC ;

Leary, SC ;

Kennaway, NG ;

Shoubridge, EA .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (01) :101-114

[7] Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle [J].

Arany, Z ;

He, HM ;

Lin, JD ;

Hoyer, K ;

Handschin, C ;

Toka, O ;

Ahmad, F ;

Matsui, T ;

Chin, S ;

Wu, PH ;

Rybkin, II ;

Shelton, JM ;

Manieri, M ;

Cinti, S ;

Schoen, FJ ;

Bassel-Duby, R ;

Rosenzweig, A ;

Ingwall, JS ;

Spiegelman, BM .

CELL METABOLISM, 2005, 1 (04) :259-271

[8] PGC-1 coactivators and skeletal muscle adaptations in health and disease [J].

Arany, Zolt .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2008, 18 (05) :426-434

[9] Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation [J].

Arany, Zoltan ;

Wagner, Bridget K. ;

Ma, Yanhong ;

Chinsomboon, Jessica ;

Laznik, Dina ;

Spiegelman, Bruce M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (12) :4721-4726

[10] HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α [J].

Arany, Zoltan ;

Foo, Shi-Yin ;

Ma, Yanhong ;

Ruas, Jorge L. ;

Bommi-Reddy, Archana ;

Girnun, Geoffrey ;

Cooper, Marcus ;

Laznik, Dina ;

Chinsomboon, Jessica ;

Rangwala, Shamina M. ;

Baek, Kwan Hyuck ;

Rosenzweig, Anthony ;

Spiegelman, Bruce M. .

NATURE, 2008, 451 (7181) :1008-U8

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