Native chemical ligation using removable Nα-(1-phenyl-2-mercaptoethyl) auxiliaries

被引：131

作者：

Botti, P ^{[1
]}

Carrasco, MR ^{[1
]}

Kent, SBH ^{[1
]}

机构：

[1] Gryphon Sci, S San Francisco, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(01)00036-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new methodology to extend native chemical ligation is presented. This method makes use of a novel 1-phenyl-2-mercaptoethyl auxiliary moiety on the alpha -amino group of a first peptide segment, the auxiliary acts as a 1-amino-2-thiol-containing functional group to effect thioester-mediated, amide-forming ligation with a second thioester-containing peptide. Subsequent facile removal of the auxiliary from the newly formed amide gives products with only native peptide structures. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：1831 / 1833

页数：3

共 12 条

[1] Extending the applicability of native chemical ligation [J].