共 12 条
Native chemical ligation using removable Nα-(1-phenyl-2-mercaptoethyl) auxiliaries
被引:131
作者:
Botti, P
[1
]
Carrasco, MR
[1
]
Kent, SBH
[1
]
机构:
[1] Gryphon Sci, S San Francisco, CA 94080 USA
关键词:
D O I:
10.1016/S0040-4039(01)00036-3
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
A new methodology to extend native chemical ligation is presented. This method makes use of a novel 1-phenyl-2-mercaptoethyl auxiliary moiety on the alpha -amino group of a first peptide segment, the auxiliary acts as a 1-amino-2-thiol-containing functional group to effect thioester-mediated, amide-forming ligation with a second thioester-containing peptide. Subsequent facile removal of the auxiliary from the newly formed amide gives products with only native peptide structures. (C) 2001 Published by Elsevier Science Ltd.
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页码:1831 / 1833
页数:3
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