New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces -: I.: Producing organism and medium components

被引:38
作者
Kimura, K [1 ]
Kagami, S
Ikeda, Y
Takahashi, H
Yoshihama, M
Kusakabe, H
Osada, H
Isono, K
机构
[1] Snow Brand Milk Prod Co Ltd, Life Sci Res Inst, Ishibashi, Tochigi 3290512, Japan
[2] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan
关键词
D O I
10.7164/antibiotics.51.640
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Liposidomycins are atypical lipid-bearing nucleoside antibiotics that inhibit bacterial peptidoglycan synthesis. A producing strain was identified as a Streptomyces sp. from its cultural characteristics and physiological properties. It produced new types of liposidomycins that lacked sulfate and/or 3-methylglutaric acid moieties present in known liposidomycins by changing medium components. Sucrose and malt extract were particularly suitable sources for specific production of the new types of liposidomycins.
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页码:640 / 646
页数:7
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