Investigation of the spontaneous transferability of a phospholipid-poly(ethylene glycol)-biotin derivative from small unilamellar phospholipid vesicles to magnetoliposomes

被引：14

作者：

De Cuyper, M ^{[1
]}

Valtonen, S ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Interdisciplinary Res Ctr, B-8500 Kortrijk, Belgium

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2001年 / 225卷 / 1-2期

关键词：

drug delivery; liposomes; phospholipid transfer; magnetoliposome; poly(ethylene glycol) (PEG); stealth; vesicles;

D O I：

10.1016/S0304-8853(00)01234-8

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

High-gradient magnetophoresis was used to monitor the spontaneous transfer between phospholipid vesicles and magnetoliposomes of dipentadecanoylphosphatidylethanolamine (DC15PE) and of its conjugate with a biotinylated PEG molecule (DC15-PEG-B). For the latter molecule, a halftime of 70 min was found, whereas DC15PE did not move. The observed transferability of PEGylated phospholipids offers a unique method for generating Stealth (R) -magnetoliposomes. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：89 / 94

页数：6

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