Pulmonary cryptococcosis misdiagnosed as smear-negative pulmonary tuberculosis with fatal consequences

被引：20

作者：

Jarvis, Joseph N. ^{[1
,2
,3
,4
]}

Wainwright, Helen ^{[5
]}

Harrison, Thomas S. ^{[3
]}

Rebe, Kevin ^{[1
,2
]}

Meintjes, Graeme ^{[1
,2
]}

机构：

[1] GF Jooste Hosp, Infect Dis Unit, Cape Town, South Africa

[2] Univ Cape Town, Dept Med, Div Infect Dis & HIV Med, ZA-7700 Rondebosch, South Africa

[3] Univ Cape Town, Dept Med, Div Infect Dis & HIV Med, ZA-7700 Rondebosch, South Africa

[4] Univ Cape Town, Inst Infect Dis & Mol Med, Desmond Tutu HIV Ctr, ZA-7700 Rondebosch, South Africa

[5] Univ Cape Town, Fac Hlth Sci, Div Anat Pathol, ZA-7925 Cape Town, South Africa

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2010年 / 14卷

基金：

英国惠康基金;

关键词：

Cryptococcosis; Cryptococcal meningitis; Pulmonary; Tuberculosis; HIV; Africa; SOUTH-AFRICA; PNEUMONIA; AIDS; MENINGITIS;

D O I：

10.1016/j.ijid.2010.02.2255

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

HIV-associated pulmonary cryptococcosis is under diagnosed, and may progress to fatal meningoencephalitis. We present a case of HIV-associated pulmonary Cryptococcus neoformans infection, initially mis-diagnosed as smear-negative pulmonary TB, which progressed to fatal cryptococcal meningitis. Autopsy series suggest that pulmonary cryptococcosis is common in African AIDS patients, and, due to limited diagnostic capacity, often mis-diagnosed as smear negative TB. Serum cryptococcal antigen testing may facilitate diagnosis in such cases. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：E310 / E312

页数：3

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