Hedgehog Signaling and Steroidogenesis

被引：46

作者：

Finco, Isabella ^{[1
]}

LaPensee, Christopher R. ^{[1
]}

Krill, Kenneth T. ^{[2
]}

Hammer, Gary D. ^{[1
,3
,4
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Endocrine Oncol Program, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Ctr Organogenesis, Ann Arbor, MI 48109 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 77 | 2015年 / 77卷

关键词：

adrenal; testis; ovary; placenta; Sf1; steroids; ACUTE REGULATORY PROTEIN; CHAIN-CLEAVAGE ENZYME; LEMLI-OPITZ-SYNDROME; FACTOR-I; SONIC-HEDGEHOG; NUCLEAR RECEPTOR; DESERT-HEDGEHOG; INDIAN HEDGEHOG; CHOLESTEROL MODIFICATION; ADRENAL DEVELOPMENT;

D O I：

10.1146/annurev-physiol-061214-111754

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Since its discovery nearly 30 years ago, the Hedgehog (Hh) signaling pathway has been shown to be pivotal in many developmental and pathophysiological processes in several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placenta. New evidence links the evolutionarily conserved Hh pathway to the steroidogenic organs, demonstrating how Hh signaling can influence their development and homeostasis and can act in concert with steroids to mediate physiological functions. In this review, we highlight the role of the components of the Hh signaling pathway in steroidogenesis of endocrine tissues.

引用

页码：105 / 129

页数：25

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