Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene

被引：14

作者：

Aoki, S ^{[1
]}

Higuchi, K ^{[1
]}

Isozumi, N ^{[1
]}

Matsui, K ^{[1
]}

Miyamoto, Y ^{[1
]}

Itoh, N ^{[1
]}

Tanaka, K ^{[1
]}

Kobayashi, M ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka 5650871, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 282卷 / 02期

关键词：

erythroid differentiation; scalarane-type sesterterpene; K562; cells; marine sponge; glycoforin A; enucleation;

D O I：

10.1006/bbrc.2001.4588

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Scalarane-type sesterterpenes, PHC-1-PHC-7, which have been isolated from a marine sponge, increased hemoglobin production in human chronic myelogenous leukemia cell line K562 at the concentration of 0.15 mug/ml. PHC-1, the major constituent, induced the expression of glycophorin A and the enucleation for K562 cells. These sesterterpenes were found to induce erythroid differentiation in K562 cells. In addition, PHC-1 induced G1 arrest of the cell cycle of K562 cells. (C) 2001 Academic Press.

引用

页码：426 / 431

页数：6

共 23 条

[1] Myrmekiosides A and B, novel mono-O-alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge of Myrmekioderma sp. [J].

Aoki, S ;

Higuchi, K ;

Kato, A ;

Murakami, N ;

Kobayashi, M .

TETRAHEDRON, 1999, 55 (52) :14865-14870

[2] Melophlins A and B, novel tetramic acids reversing the phenotype of ras-transformed cells, from the marine sponge Melophlus sarassinorum [J].

Aoki, S ;

Higuchi, K ;

Ye, Y ;

Satari, R ;

Kobayashi, M .

TETRAHEDRON, 2000, 56 (13) :1833-1836

[3]

CALLUS BA, 1995, HEMOGLOBIN, V19, P7

[4]

DERMIME S, 1993, BLOOD, V82, P1573

[5] A NOVEL MACROMOLECULAR STRUCTURE IS A TARGET OF THE PROMYELOCYTE-RETINOIC ACID RECEPTOR ONCOPROTEIN [J].

DYCK, JA ;

MAUL, GG ;

MILLER, WH ;

CHEN, JD ;

KAKIZUKA, A ;

EVANS, RM .

CELL, 1994, 76 (02) :333-343

[6] Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies [J].

Harris, CC .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1996, 88 (20) :1442-1455

[7] FUNDAMENTALS OF CHEMOTHERAPY OF MYELOID-LEUKEMIA BY INDUCTION OF LEUKEMIA-CELL DIFFERENTIATION [J].

HOZUMI, M .

ADVANCES IN CANCER RESEARCH, 1983, 38 :121-169

[8] DIFFERENTIATION OF A CELL LINE OF MYELOID LEUKEMIA [J].

ICHIKAWA, Y .

JOURNAL OF CELLULAR PHYSIOLOGY, 1969, 74 (03) :223-&

[9] SENSITIVE ASSAY SYSTEMS FOR DETECTION OF HEMOGLOBIN WITH 2,7-DIAMINOFLUORENE - HISTOCHEMISTRY AND COLORIMETRY FOR ERYTHRODIFFERENTIATION [J].

KAIHO, SI ;

MIZUNO, K .

ANALYTICAL BIOCHEMISTRY, 1985, 149 (01) :117-120

[10] 5 NEW C-26 TETRACYCLIC TERPENES FROM A SPONGE (LENDENFELDIA SP) [J].

KAZLAUSKAS, R ;

MURPHY, PT ;

WELLS, RJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1982, 35 (01) :51-59

← 1 2 3 →