Encouraging initial response of restless legs syndrome to pramipexole

被引：58

作者：

Becker, PM

Ondo, W

Sharon, D

机构：

[1] Baylor Coll Med, Houston, TX 77030 USA

[2] Univ Texas, SW Med Ctr, Dallas, TX USA

[3] Sleep Med Associates Texas, Dallas, TX USA

来源：

NEUROLOGY | 1998年 / 51卷 / 04期

关键词：

D O I：

10.1212/WNL.51.4.1221

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Restless legs syndrome (RLS) is a common condition that results in uncomfortable sensations and an urge to move the limbs. Two centers tested a new dopamine agonist, pramipexole, in 23 patients with RLS in a time-limited, open-label, clinical trial. After 4 weeks or more, 19 patients reported significant improvement as assessed by the short International Restless Legs Syndrome Study Group questionnaire (p < 0.0001). These encouraging preliminary results justify larger, controlled trials for pramipexole in patients with RLS.

引用

收藏

页码：1221 / 1223

页数：3

相关论文

共 9 条

[1] Augmentation of the restless legs syndrome with carbidopa/levodopa [J].

Allen, RP ;

Earley, CJ .

SLEEP, 1996, 19 (03) :205-213

[2] DOPAMINERGIC AGENTS IN RESTLESS LEGS SYNDROME AND PERIODIC LIMB MOVEMENTS OF SLEEP - RESPONSE AND COMPLICATIONS OF EXTENDED TREATMENT IN 49 CASES [J].

BECKER, PM ;

JAMIESON, AO ;

BROWN, WD .

SLEEP, 1993, 16 (08) :713-716

[3] Pergolide and carbidopa/levodopa treatment of the restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients [J].

Earley, CJ ;

Allen, RP .

SLEEP, 1996, 19 (10) :801-810

[4]

Kieburtz K, 1997, JAMA-J AM MED ASSOC, V278, P125

[5] Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: A study of 133 patients diagnosed with new standard criteria [J].

Montplaisir, J ;

Boucher, S ;

Poirier, G ;

Lavigne, G ;

Lapierre, O ;

Lesperance, P .

MOVEMENT DISORDERS, 1997, 12 (01) :61-65

[6] Restless legs syndrome: Clinicoetiologic correlates [J].

Ondo, W ;

Jankovic, J .

NEUROLOGY, 1996, 47 (06) :1435-1441

[7] Pergolide in the management of restless legs syndrome: An extended study [J].

Silber, MH ;

Shepard, JW ;

Wisbey, JA .

SLEEP, 1997, 20 (10) :878-882

[8] A DOUBLE-BLIND RANDOMIZED CROSSOVER TRIAL OF BROMOCRIPTINE AND PLACEBO IN RESTLESS LEGS SYNDROME [J].

WALTERS, AS ;

HENING, WA ;

KAVEY, N ;

CHOKROVERTY, S ;

GIDROFRANK, S .

ANNALS OF NEUROLOGY, 1988, 24 (03) :455-458

[9] TOWARD A BETTER DEFINITION OF THE RESTLESS LEGS SYNDROME [J].

WALTERS, AS .

MOVEMENT DISORDERS, 1995, 10 (05) :634-642