Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis

被引：45

作者：

Rolain, JM ^{[1
]}

Mallet, MN ^{[1
]}

Raoult, D ^{[1
]}

机构：

[1] Univ Mediterranee, Fac Med, Inst Federat Rech 48, Unite Rickettsies,CNRS,UMR 6020, F-13385 Marseille 05, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2003年 / 188卷 / 09期

关键词：

D O I：

10.1086/379082

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recommended treatment for Q fever endocarditis is a combination of doxycycline and hydroxychloroquine. We found a correlation between serum doxycycline concentrations and decreases in levels of phase 1 Coxiella burnetii antibodies, in 24 patients with Q fever endocarditis. Patients who had a >2-fold decrease in levels of phase 1 antibodies had serum doxycycline concentrations higher than those of the other patients (mean +/- SD 5.29 +/- 1.75 3.14 +/- 1.40 mug/mL; P = .003). We recommend adjusting the posology of doxycycline to achieve a serum concentration of at least 5 mug/mL.

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页码：1322 / 1325

页数：4

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