共 15 条
Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo
被引:337
作者:

Yeh, ETH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA

Zhang, S
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h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA

Wu, HD
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h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA

Körbling, M
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h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA

Willerson, JT
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h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA

Estrov, Z
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h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA
机构:
[1] Univ Texas, MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA
[3] Univ Texas, MD Anderson Canc Ctr, Dept Bioimmunotherapy, Houston, TX 77030 USA
[4] Univ Houston, Hlth Sci Ctr, Houston, TX USA
[5] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX USA
关键词:
cells;
muscle;
smooth;
endothelium;
myocyte;
D O I:
10.1161/01.CIR.0000099501.52718.70
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background - Adult human peripheral blood cells have been shown to differentiate into mature cells of nonhematopoietic tissues, such as hepatocytes and epithelial cells of the skin and gastrointestinal track. We investigated whether these cells could also transdifferentiate into human cardiomyocytes, mature endothelial cells, and smooth muscle cells in vivo. Methods and Results - Myocardial infarction was created in SCID mice by occluding the left anterior descending coronary artery, after which adult peripheral blood CD34(+) cells were injected into the tail vein. Hearts were harvested 2 months after injection and stained for human leukocyte antigen (HLA) and markers for cardiomyocytes, endothelial cells, and smooth muscle cells. Cardiomyocytes, endothelial cells, and smooth muscle cells that bear HLA were identified in the infarct and peri-infarct regions of the mouse hearts. In a separate experiment, CD34(+) cells were injected intraventricularly into mice without experimental myocardial infarction. HLA-positive myocytes and smooth muscle cells could only be identified in 1 of these mice killed at different time points. Conclusions - Adult peripheral blood CD34(+) cells can transdifferentiate into cardiomyocytes, mature endothelial cells, and smooth muscle cells in vivo. However, transdifferentiation is augmented significantly by local tissue injury. The use of peripheral blood CD34(+) cells for cell-based therapy should greatly simplify the procurement of cells for the regeneration of damaged myocardium.
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页码:2070 / 2073
页数:4
相关论文
共 15 条
[1]
Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes
[J].
Badorff, C
;
Brandes, RP
;
Popp, R
;
Rupp, S
;
Urbich, C
;
Aicher, A
;
Fleming, I
;
Busse, R
;
Zeiher, A
;
Dimmeler, S
.
CIRCULATION,
2003, 107 (07)
:1024-1032

Badorff, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Brandes, RP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Popp, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Rupp, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Urbich, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Aicher, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Fleming, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Busse, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Zeiher, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

Dimmeler, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany
[2]
ANALYSIS OF THE EFFECTS OF TUMOR-NECROSIS-FACTOR INHIBITORS ON HUMAN HEMATOPOIESIS
[J].
FERRAJOLI, A
;
TALPAZ, M
;
KURZROCK, R
;
ESTROV, Z
.
STEM CELLS,
1993, 11 (02)
:112-119

FERRAJOLI, A
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BIOL STUDIES SECT,BOX 302,HOUSTON,TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BIOL STUDIES SECT,BOX 302,HOUSTON,TX 77030

TALPAZ, M
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BIOL STUDIES SECT,BOX 302,HOUSTON,TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BIOL STUDIES SECT,BOX 302,HOUSTON,TX 77030

KURZROCK, R
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BIOL STUDIES SECT,BOX 302,HOUSTON,TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BIOL STUDIES SECT,BOX 302,HOUSTON,TX 77030

ESTROV, Z
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BIOL STUDIES SECT,BOX 302,HOUSTON,TX 77030 UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MED ONCOL,BIOL STUDIES SECT,BOX 302,HOUSTON,TX 77030
[3]
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
[J].
Jackson, KA
;
Majka, SM
;
Wang, HG
;
Pocius, J
;
Hartley, CJ
;
Majesky, MW
;
Entman, ML
;
Michael, LH
;
Hirschi, KK
;
Goodell, MA
.
JOURNAL OF CLINICAL INVESTIGATION,
2001, 107 (11)
:1395-1402

Jackson, KA
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Majka, SM
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Wang, HG
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Pocius, J
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Hartley, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Majesky, MW
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Entman, ML
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Michael, LH
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Hirschi, KK
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

Goodell, MA
论文数: 0 引用数: 0
h-index: 0
机构: Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
[4]
Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia
[J].
Kawamoto, A
;
Tkebuchava, T
;
Yamaguchi, JI
;
Nishimura, H
;
Yoon, YS
;
Milliken, C
;
Uchida, S
;
Masuo, O
;
Iwaguro, H
;
Ma, H
;
Hanley, A
;
Silver, M
;
Kearney, M
;
Losordo, DW
;
Isner, JM
;
Asahara, T
.
CIRCULATION,
2003, 107 (03)
:461-468

Kawamoto, A
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Tkebuchava, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Yamaguchi, JI
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Nishimura, H
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Yoon, YS
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Milliken, C
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Uchida, S
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Masuo, O
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Iwaguro, H
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Ma, H
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Hanley, A
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Silver, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Kearney, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Losordo, DW
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Isner, JM
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA

Asahara, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Div Cardiovasc Res, Sch Med, Boston, MA 02135 USA
[5]
Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts
[J].
Klug, MG
;
Soonpaa, MH
;
Koh, GY
;
Field, LJ
.
JOURNAL OF CLINICAL INVESTIGATION,
1996, 98 (01)
:216-224

Klug, MG
论文数: 0 引用数: 0
h-index: 0
机构:
INDIANA UNIV, KRANNERT INST CARDIOL, SCH MED, INDIANAPOLIS, IN 46202 USA INDIANA UNIV, KRANNERT INST CARDIOL, SCH MED, INDIANAPOLIS, IN 46202 USA

Soonpaa, MH
论文数: 0 引用数: 0
h-index: 0
机构:
INDIANA UNIV, KRANNERT INST CARDIOL, SCH MED, INDIANAPOLIS, IN 46202 USA INDIANA UNIV, KRANNERT INST CARDIOL, SCH MED, INDIANAPOLIS, IN 46202 USA

Koh, GY
论文数: 0 引用数: 0
h-index: 0
机构:
INDIANA UNIV, KRANNERT INST CARDIOL, SCH MED, INDIANAPOLIS, IN 46202 USA INDIANA UNIV, KRANNERT INST CARDIOL, SCH MED, INDIANAPOLIS, IN 46202 USA

Field, LJ
论文数: 0 引用数: 0
h-index: 0
机构:
INDIANA UNIV, KRANNERT INST CARDIOL, SCH MED, INDIANAPOLIS, IN 46202 USA INDIANA UNIV, KRANNERT INST CARDIOL, SCH MED, INDIANAPOLIS, IN 46202 USA
[6]
Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
[J].
Kocher, AA
;
Schuster, MD
;
Szabolcs, MJ
;
Takuma, S
;
Burkhoff, D
;
Wang, J
;
Homma, S
;
Edwards, NM
;
Itescu, S
.
NATURE MEDICINE,
2001, 7 (04)
:430-436

Kocher, AA
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Dept Surg, New York, NY 10027 USA

Schuster, MD
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Dept Surg, New York, NY 10027 USA

Szabolcs, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Dept Surg, New York, NY 10027 USA

Takuma, S
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Dept Surg, New York, NY 10027 USA

论文数: 引用数:
h-index:
机构:

Wang, J
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Dept Surg, New York, NY 10027 USA

Homma, S
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Dept Surg, New York, NY 10027 USA

Edwards, NM
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Dept Surg, New York, NY 10027 USA

Itescu, S
论文数: 0 引用数: 0
h-index: 0
机构:
Columbia Univ, Dept Surg, New York, NY 10027 USA Columbia Univ, Dept Surg, New York, NY 10027 USA
[7]
Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells.
[J].
Korbling, M
;
Katz, RL
;
Khanna, A
;
Ruifrok, AC
;
Rondon, G
;
Albitar, M
;
Champlin, RE
;
Estrov, Z
.
NEW ENGLAND JOURNAL OF MEDICINE,
2002, 346 (10)
:738-746

Korbling, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

Katz, RL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

Khanna, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

Ruifrok, AC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

Rondon, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

Albitar, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

Champlin, RE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

Estrov, Z
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA
[8]
Adult-derived stem cells from the liver become myocytes in the heart in vivo
[J].
Malouf, NN
;
Coleman, WB
;
Grisham, JW
;
Lininger, RA
;
Madden, VJ
;
Sproul, M
;
Anderson, PAW
.
AMERICAN JOURNAL OF PATHOLOGY,
2001, 158 (06)
:1929-1935

Malouf, NN
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Dept Pathol, Chapel Hill, NC 27514 USA

Coleman, WB
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Dept Pathol, Chapel Hill, NC 27514 USA

Grisham, JW
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Dept Pathol, Chapel Hill, NC 27514 USA

Lininger, RA
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Dept Pathol, Chapel Hill, NC 27514 USA

Madden, VJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Dept Pathol, Chapel Hill, NC 27514 USA

Sproul, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Dept Pathol, Chapel Hill, NC 27514 USA

Anderson, PAW
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Dept Pathol, Chapel Hill, NC 27514 USA
[9]
Bone marrow cells regenerate infarcted myocardium
[J].
Orlic, D
;
Kajstura, J
;
Chimenti, S
;
Jakoniuk, I
;
Anderson, SM
;
Li, BS
;
Pickel, J
;
McKay, R
;
Nadal-Ginard, B
;
Bodine, DM
;
Leri, A
;
Anversa, P
.
NATURE,
2001, 410 (6829)
:701-705

Orlic, D
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Kajstura, J
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Chimenti, S
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Jakoniuk, I
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Anderson, SM
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Li, BS
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Pickel, J
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

McKay, R
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Nadal-Ginard, B
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Bodine, DM
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Leri, A
论文数: 0 引用数: 0
h-index: 0
机构: New York Med Coll, Dept Med, Valhalla, NY 10595 USA

Anversa, P
论文数: 0 引用数: 0
h-index: 0
机构:
New York Med Coll, Dept Med, Valhalla, NY 10595 USA New York Med Coll, Dept Med, Valhalla, NY 10595 USA
[10]
Autologous cell transplantation for the treatment of damaged myocardium
[J].
Penn, MS
;
Francis, GS
;
Ellis, SG
;
Young, JB
;
McCarthy, PM
;
Topol, EJ
.
PROGRESS IN CARDIOVASCULAR DISEASES,
2002, 45 (01)
:21-32

Penn, MS
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Dept Cardiovasc Med, Expt Anim Lab, Cleveland, OH 44195 USA

Francis, GS
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Dept Cardiovasc Med, Expt Anim Lab, Cleveland, OH 44195 USA

Ellis, SG
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Dept Cardiovasc Med, Expt Anim Lab, Cleveland, OH 44195 USA

Young, JB
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Dept Cardiovasc Med, Expt Anim Lab, Cleveland, OH 44195 USA

McCarthy, PM
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Dept Cardiovasc Med, Expt Anim Lab, Cleveland, OH 44195 USA

Topol, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Cleveland Clin Fdn, Dept Cardiovasc Med, Expt Anim Lab, Cleveland, OH 44195 USA