Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells

被引：64

作者：

Ito, Hideyuki ^{[1
]}

Sun, Xiu-Lan ^{[1
]}

Watanabe, Makiko ^{[2
]}

Okamoto, Motoi ^{[2
]}

Hatano, Tsutomu ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pharmacognosy, Okayama 7008530, Japan

[2] Okayama Univ, Dept Med Technol, Grad Sch Hlth Sci, Shikata, Okayama 7008558, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 03期

关键词：

neurite outgrowth; hippocampal neurons; polyphenols; chlorogenic acid; m-coumaric acid;

D O I：

10.1271/bbb.70670

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We evaluated the neurotrophic activity of dietary polyphenols by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. Among the tested compounds, chlorogenic acid and its metabolite, m-coumaric acid, together with catechins and flavanone, were found to promote neuronal differentiation comparable to the phytochemical, honokiol, which has been reported to show potent neurotrophic activity. The present findings may contribute to the development of further neurotrophic studies on dietary polyphenols and their metabolites.

引用

页码：885 / 888

页数：4

共 19 条

[1] Clifford MN, 1999, J SCI FOOD AGR, V79, P362, DOI [10.1002/(SICI)1097-0010(19990301)79:3&lt
[2] 362::AID-JSFA256&gt
[3] 3.0.CO
[4] 2-D, 10.1002/(SICI)1097-0010(19990301)79:3<362::AID-JSFA256>3.0.CO
[5] 2-D]
[6] CZOK G, 1961, ARZNEIMITTEL-FORSCH, V11, P448
[7] Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids
Déprez, S
Brezillon, C
Rabot, S
Philippe, C
Mila, I
Lapierre, C
Scalbert, A
[J]. JOURNAL OF NUTRITION, 2000, 130 (11) : 2733 - 2738
[8] Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons
Fukuyama, Y
Nakade, K
Minoshima, Y
Yokoyama, R
Zhai, HF
Mitsumoto, Y
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (08) : 1163 - 1166
[9] ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR
GREENE, LA
TISCHLER, AS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (07) : 2424 - 2428
[10] HACH B, 1971, ARZNEI-FORSCHUNG, V21, P23

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