Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga

被引：176

作者：

Alekseyenko, T. V.

Zhanayeva, S. Ya. ^{[1
]}

Venediktova, A. A.

Zvyagintseva, T. N.

Kuznetsova, T. A.

Besednova, N. N.

Korolenko, T. A.

机构：

[1] Russian Acad Med Sci, Siberian Div, Inst Physiol, Novosibirsk, Russia

[2] Russian Acad Sci, Fa Eastern Div, Pacific Inst Organ Biochem, Vladivostok, Russia

[3] Russian Acad Med Sci, Siberian Div, Inst Epidemiol & Microbiol, Vladivostok, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 143卷 / 06期

关键词：

mice; Lewis lung adenocarcinoma; fucoidan; cyclophosphamide; cathepsins B; L; and D;

D O I：

10.1007/s10517-007-0226-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57B1/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the antimetastatic, but not antitumor activities of cyclophosphamide. Fucoidan in a dose of 25 mg/kg potentiated the toxic effect of cyclophosphamide.

引用

页码：730 / 732

页数：3

共 9 条

[1] The role of cathepsin D and PAI-1 in primary invasive breast cancer as prognosticators and predictors of treatment benefit with adjuvant tamoxifen [J].