Absence of genetic diversity reduction in the HIV-1 integrated proviral LTR sequence population during successful combination therapy

被引：9

作者：

Ibáñez, A ^{[1
]}

Clotet, B ^{[1
]}

Martínez, MA ^{[1
]}

机构：

[1] Hosp Univ Germans Tries & Pujol, Fdn IrsiCaixa, Badalona 08916, Spain

来源：

VIROLOGY | 2001年 / 282卷 / 01期

关键词：

D O I：

10.1006/viro.2000.0840

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the integrated proviral LTR sequence variation in four patients on highly active antiretroviral therapy (HAART). Integrated proviral fragments of LTR taken from four time points were PCR amplified from PBMCs and 10 to 12 individual clones were sequenced for each time point. Intrasample genetic distances and phylogenetic reconstruction of all LTR sequences demonstrated that 1-2 years of successful HAART did not significantly reduce the genetic repertoire of the integrated reservoir of HIV-1. (C) 2001 Academic Press.

引用

页码：1 / 5

页数：5

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