Molecular orbital studies relating to potential anticancer activity of cis-platinum ammines

被引：3

作者：

Boudreaux, EA ^{[1
]}

机构：

[1] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

来源：

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY | 2001年 / 83卷 / 3-4期

关键词：

cis-platinum; molecular orbital calculations; ammine nitrogen;

D O I：

10.1002/qua.1216

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The binding of platinum(II) diammines to 1-methylcytosine and guanine has been reevaluated from earlier published molecular orbital calculations, in which the Lowdin overlap charge density has been defined and evaluated for platinum-ammine bonds in the Pt(II) diammine drugs and the P-N bonds involved with 1-methylcytosine and guanine. It is also shown that the effectiveness of anticancer activity is reduced in the Pt(II) diammine drugs, with increasing methyl substitution on the ammine nitrogen. (C) 2001 John Wiley & Sons, Inc.

引用

页码：255 / 258

页数：4