A meta-analysis of whole genome linkage screens in multiple sclerosis

被引：106

作者：

机构：

[1] Vanderbilt Univ, Program Human Genet, Nashville, TN 37240 USA

[2] Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA

[3] Univ Sydney, Westmead Hosp, Inst Immunol & Allergy Res, Westmead Millennium Inst, Sydney, NSW 2145, Australia

[4] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[5] Univ Oxford, Dept Neurol, Oxford, England

[6] Natl Publ Hlth Inst, Dept Human Mol Genet, Helsinki, Finland

[7] Univ Calif Los Angeles, Dept Human Genet, David Geffen Sch Med, Los Angeles, CA USA

[8] IRCAD, Novara, Italy

[9] Univ Cagliari, Dipartimento Neurosci, Ctr Sclerosi Multipla, Osped Binaghi, I-09126 Cagliari, Italy

[10] Huddinge Univ Hosp, Karolinska Inst, Dept Neurol, Stockholm, Sweden

[11] Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34390 Istanbul, Turkey

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 143卷 / 1-2期

关键词：

multiple sclerosis; genome; linkage; meta-analysis;

D O I：

10.1016/j.jneuroim.2003.08.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Linkage studies in complex diseases like multiple sclerosis, where the effects attributable to individual loci are modest, are critically dependent upon the number of families included. We have combined the raw genotyping data from all published genome linkage screens in multiple sclerosis and thereby performed a linkage analysis including 719 families studied with a weighted average of 359 microsatellite markers per family (range 257-453) providing an average marker separation of 10.2 cM. Linkage with genome-wide significance is confirmed in the HLA region on chromosome 6p21. In addition, two novel regions suggestive of linkage are seen (17q21 and 22q13). Our simulations would imply that the number of peaks with NPL scores greater than or equal to 2.1 exceeds the number expected by chance alone. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：39 / 46

页数：8

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