Sharing gene expression data: an array of options

被引:41
作者
Geschwind, DH [1 ]
机构
[1] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA
关键词
D O I
10.1038/35077576
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sharing of microarray data has many advantages for the scientific and biomedical community, and should be advocated by neuroscience journals. The goals of sharing are manifold, and include improving analysis and confidence in results, and facilitating global comparisons between experiments, while at the same time, not penalizing those who share. The sharing of microarray data poses unique challenges relative to more generic data such as DNA sequences. These challenges are surmountable, and various sharing formats are possible. Centralized non-commercial databases are being developed to facilitate this process.
引用
收藏
页码:435 / 438
页数:4
相关论文
共 22 条
[1]   One-stop shop for microarray data - Is a universal, public DNA-microarray database a realistic goal? [J].
Brazma, A ;
Robinson, A ;
Cameron, G ;
Ashburner, M .
NATURE, 2000, 403 (6771) :699-700
[2]   Exploring the new world of the genome with DNA microarrays [J].
Brown, PO ;
Botstein, D .
NATURE GENETICS, 1999, 21 (Suppl 1) :33-37
[3]   Profiling expression patterns and isolating differentially expressed genes by cDNA microarray system with colorimetry detection [J].
Chen, JJW ;
Wu, R ;
Yang, PC ;
Huang, JY ;
Sher, YP ;
Han, MH ;
Kao, WC ;
Lee, PJ ;
Chiu, TF ;
Chang, F ;
Chu, YW ;
Wu, CW ;
Peck, K .
GENOMICS, 1998, 51 (03) :313-324
[4]   An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis [J].
Chiang, LW ;
Grenier, JM ;
Ettwiller, L ;
Jenkins, LP ;
Ficenec, D ;
Martin, J ;
Jin, FY ;
DiStefano, PS ;
Wood, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) :2814-2819
[5]  
COLLINS FS, 2001, PROJECT CANC, V91, P221
[6]  
DeRisi J, 1996, NAT GENET, V14, P457
[7]   Exploring the metabolic and genetic control of gene expression on a genomic scale [J].
DeRisi, JL ;
Iyer, VR ;
Brown, PO .
SCIENCE, 1997, 278 (5338) :680-686
[8]  
Eberwine J, 1996, BIOTECHNIQUES, V20, P584
[9]   Mice, microarrays, and the genetic diversity of the brain [J].
Geschwind, DH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (20) :10676-10678
[10]   A genetic analysis of neural progenitor differentiation [J].
Geschwind, DH ;
Ou, J ;
Easterday, MC ;
Dougherty, JD ;
Jackson, RL ;
Chen, ZG ;
Antoine, H ;
Terskikh, A ;
Weissman, IL ;
Nelson, SF ;
Kornblum, HI .
NEURON, 2001, 29 (02) :325-339