Multiple sclerosis: trapped in deadly glue

被引:55
作者
Platten, M
Steinman, L
机构
[1] Univ Tubingen, Dept Neurol, D-7400 Tubingen, Germany
[2] Univ Tubingen, Dept Gen Neurol, D-7400 Tubingen, Germany
[3] Univ Tubingen, Hertie Inst Clin Brain Res, D-7400 Tubingen, Germany
[4] Stanford Univ, Dept Neurol & Neurol Sci, Beckman Ctr Mol Med, Stanford, CA 94305 USA
[5] Stanford Univ, Interdept Program Immunol, Stanford, CA 94305 USA
关键词
D O I
10.1038/nm0305-252
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two forms of glial cells have distinct roles in the neuroinflammatory cascade of a mouse model of multiple sclerosis. These cells serve as key targets for therapeutic intervention (pages 328–334 and 335–339).
引用
收藏
页码:252 / 253
页数:2
相关论文
共 19 条
[1]   IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis [J].
Becher, B ;
Durell, BG ;
Noelle, RJ .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (08) :1186-1191
[2]   Antibodies to CD44 and integrin α4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment [J].
Brocke, S ;
Piercy, C ;
Steinman, L ;
Weissman, IL ;
Veromaa, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6896-6901
[3]   Microglia as liaisons between the immune and central nervous systems: Functional implications for multiple sclerosis [J].
Carson, MJ .
GLIA, 2002, 40 (02) :218-231
[4]  
Carson MJ, 1998, GLIA, V22, P72, DOI 10.1002/(SICI)1098-1136(199801)22:1<72::AID-GLIA7>3.0.CO
[5]  
2-A
[6]   The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease [J].
Chabas, D ;
Baranzini, SE ;
Mitchell, D ;
Bernard, CCA ;
Rittling, SR ;
Denhardt, DT ;
Sobel, RA ;
Lock, C ;
Karpuj, M ;
Pedotti, R ;
Heller, R ;
Oksenberg, JR ;
Steinman, L .
SCIENCE, 2001, 294 (5547) :1731-1735
[7]   Bone marrow transdifferentiation in brain after transplantation: a retrospective study [J].
Cogle, CR ;
Yachnis, AT ;
Laywell, ED ;
Zander, DS ;
Wingard, JR ;
Steindler, DA ;
Scott, EW .
LANCET, 2004, 363 (9419) :1432-1437
[8]   Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice [J].
Eglitis, MA ;
Mezey, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :4080-4085
[9]   BOTH ANTI-CD11A (LFA-I) AND ANTI-CD11B (MAC-1) THERAPY DELAY THE ONSET AND DIMINISH THE SEVERITY OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS [J].
GORDON, EJ ;
MYERS, KJ ;
DOUGHERTY, JP ;
ROSEN, H ;
RON, Y .
JOURNAL OF NEUROIMMUNOLOGY, 1995, 62 (02) :153-160
[10]   Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis [J].
Greter, M ;
Heppner, FL ;
Lemos, MP ;
Odermatt, BM ;
Goebels, N ;
Laufer, T ;
Noelle, RJ ;
Becher, B .
NATURE MEDICINE, 2005, 11 (03) :328-334