Longitudinally mapping the influence of sex and androgen signaling on the dynamics of human cortical maturation in adolescence

被引：204

作者：

Raznahan, Armin ^{[1
,2
]}

Lee, Yohan ^{[1
]}

Stidd, Reva ^{[1
]}

Long, Robert ^{[1
]}

Greenstein, Dede ^{[1
]}

Clasen, Liv ^{[1
]}

Addington, Anjene ^{[1
]}

Gogtay, Nitin ^{[1
]}

Rapoport, Judith L. ^{[1
]}

Giedd, Jay N. ^{[1
]}

机构：

[1] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA

[2] Kings Coll London, Dept Child & Adolescent Psychiat, Inst Psychiat, London SE5 8A8, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 39期

基金：

美国国家卫生研究院;

关键词：

sex differences; brain; cortex; development; androgen receptor; CEREBRAL-CORTEX; RECEPTOR GENE; BRAIN; TESTOSTERONE; CHILDHOOD; BEHAVIOR; TRACT; TRANSACTIVATION; TRAJECTORIES; POLYMORPHISM;

D O I：

10.1073/pnas.1006025107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Humans have systematic sex differences in brain-related behavior, cognition, and pattern of mental illness risk. Many of these differences emerge during adolescence, a developmental period of intense neurostructural and endocrine change. Here, by creating "movies" of sexually dimorphic brain development using longitudinal in vivo structural neuroimaging, we show regionally specific sex differences in development of the cerebral cortex during adolescence. Within cortical subsystems known to underpin domains of cognitive behavioral sex difference, structural change is faster in the sex that tends to perform less well within the domain in question. By stratifying participants through molecular analysis of the androgen receptor gene, we show that possession of an allele conferring more efficient functioning of this sex steroid receptor is associated with "masculinization" of adolescent cortical maturation. Our findings extend models first established in rodents, and suggest that in humans too, sex and sex steroids shape brain development in a spatiotemporally specific manner, within neural systems known to underpin sexually dimorphic behaviors.

引用

页码：16988 / 16993

页数：6

共 54 条

[1] Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice [J].