BCR/ABL and leukemia

被引：29

作者：

Butturini, A

Arlinghaus, RB

Gale, RP

机构：

[1] SALICK HLTH CARE INC,LOS ANGELES,CA 90048

[2] MD ANDERSON HOSP & TUMOR INST,DEPT MOL PATHOL,HOUSTON,TX

[3] UNIV PARMA,DEPT PEDIAT,I-43100 PARMA,ITALY

来源：

LEUKEMIA RESEARCH | 1996年 / 20卷 / 06期

关键词：

BCR/ABL; Ph(1)-chromosome; chronic myelogenous leukemia; oncogenes;

D O I：

10.1016/0145-2126(95)00057-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review focuses on the role of the chimeric BCR/ABL gene in leukemia development. First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We then review data regarding transforming activity of BCR/ABL. Third, we discuss the complex interactions between BCR/ABL and leukemia phenotype. We conclude with a brief discussion of possible therapeutic implications of these data. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：523 / 529

页数：7

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