Origin and evolution of flavivirus 5′UTRs and panhandles:: Trans-terminal duplications?

被引：43

作者：

Gritsun, T. S. ^{[1
]}

Gould, E. A. ^{[1
]}

机构：

[1] Ctr Ecol & Hydrol, Oxford 0X13SR, England

来源：

VIROLOGY | 2007年 / 366卷 / 01期

基金：

英国自然环境研究理事会;

关键词：

flaviviruses; alignment; 5'UTR; promoter; enhancer; panhandle; cyclisation;

D O I：

10.1016/j.virol.2007.04.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Flavivirus replication is mediated by interactions between complementary ssRNA sequences of the 5'- and 3'-termini that form dsRNA cyclisation stems or panhandles, varying in length, sequence and specific location in the mosquito-bome, tick-borne, non-vectored and non-classified flaviviruses. In this manuscript we manually aligned the flavivirus 5'UTRs and adjacent capsid genes and revealed significantly more homology than has hitherto been identified. Analysis of the alignments revealed that the panhandles represent evolutionary remnants of a long cyclisation domain that probably emerged through duplication of one of the UTR termini. (c) 2007 Elsevier Inc. All rights reserved.

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页码：8 / 15

页数：8

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