Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo

被引：63

作者：

Li, Na ^{[1
]}

Fan, Lu-Lu ^{[1
]}

Sun, Guo-Ping ^{[1
]}

Wan, Xin-An ^{[1
]}

Wang, Zhang-Gui ^{[1
]}

Wu, Qiang ^{[2
]}

Wang, Hua ^{[3
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Dept Pathol, Hefei 230032, Anhui, Peoples R China

[3] Anhui Prov Hosp, Dept Oncol, Hefei 230032, Anhui, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 35期

基金：

中国国家自然科学基金;

关键词：

Paeonol; Gastric cancer; Cell proliferation; Apoptosis; CELL LINES; APOPTOSIS INDUCTION; ANTIPROLIFERATION; CISPLATIN; PATHWAY;

D O I：

10.3748/wjg.v16.i35.4483

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM To investigate the anti-tumor effects of paeonol in gastric cancer cell proliferation and apoptosis in vitro and in vivo METHODS Murine gastric cancer cell line mouse forestomach carcinoma (MFC) or human gastric cancer cell line SGC-7901 was cultured in the presence or absence of paeonol Cell proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and cell cycle and apoptosis by flow cytometry and TUNEL staining Tumor growth after subcutaneous implantation of MFC cells in mice was monitored, and the effects of treatment with paeonol were determined RESULTS In vitro, paeonol caused dose-dependent inhibition on cell proliferation and induced apoptosis Cell cycle analysis revealed a decreased proportion of cells in G0/G1 phase, with arrest at S Paeonol treatment in gastric cancer cell line MFC and SGC-790 cells significantly reduced the expression of Bcl-2 and increased the expression of Bax in a concentration-related manner Administration of paeonol to MFC tumor-bearing mice significantly lowered the tumor growth and caused tumor regression CONCLUSION Paeonol has significantly growth-inhibitory and apoptosis-inducing effects in gastric cancer cells both in vitro and in vivo (C) 2010 Baishideng All rights reserved

引用

页码：4483 / 4490

页数：8

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