Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development

被引：55

作者：

Leimeister, C ^{[1
]}

Schumacher, N ^{[1
]}

Gessler, M ^{[1
]}

机构：

[1] Univ Wurzburg, Theodor Boveri Inst, Biozentrum, D-97074 Wurzburg, Germany

来源：

GENE EXPRESSION PATTERNS | 2003年 / 3卷 / 05期

关键词：

kidney; metanephros; nephrogenesis; renal vesicles; comma-shaped body; S-shaped body; ureter; collecting ducts; glomerulus; blood vessels; Notch; Dll; Lfng; Jag; Hey; proximal tubule;

D O I：

10.1016/S1567-133X(03)00114-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interaction of neighboring cells via Notch signalling leads to cell fate determination, differentiation and patterning of highly organized tissues. Mice with targeted disruption of genes from the Notch signal transduction pathway display defects in the developing somites, neurogenic structures, blood vessels, heart and other organs. Recent studies have added requirements for Notch signalling during kidney, pancreas and thymus morphogenesis. Here, we describe the expression of all four receptors (Notch 1-4), the five transmembrane ligands (Dill, 3, 4, Jag 1 and Jag2), intracellular effectors (the Hey genes) and extracellular modulators (Lfng, Mfng, Rfng) in the developing mouse metanephros. Our results point to a Lfng-dependent role for Notch signalling in the development of nephron segments, especially the proximal tubules. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：595 / 598

页数：4

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