Interactions Between Proteins and Platinum-Containing Anti-Cancer Drugs

被引：36

作者：

Bischin, Cristina ^{[1
]}

Lupan, Alexandru ^{[1
]}

Taciuc, Vicentiu ^{[1
]}

Silaghi-Dumitrescu, Radu ^{[1
]}

机构：

[1] Univ Babes Bolyai, Dept Chem & Chem Engn, RO-400028 Cluj Napoca, Romania

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2011年 / 11卷 / 03期

关键词：

Cisplatin; cysteine; methionine; adduct; toxicity; resistance; HUMAN SERUM-ALBUMIN; CRYSTAL-STRUCTURE; MASS-SPECTROMETRY; CYTOCHROME-C; ESCHERICHIA-COLI; STRUCTURAL BASIS; LIQUID-CHROMATOGRAPHY; CISPLATIN RESISTANCE; BINDING-SITES; CELL-LINES;

D O I：

10.2174/138955711795049844

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cisplatin and its congeners are well-known to exert their therapeutic effects on cancer via interaction with DNA in the cell nucleus. On the other hand, the undesirable side-effects of these drugs appear to also be linked, at least to some extent, to interaction of the platinum with proteins and peptides. For other classes of anticancer drugs, interaction with proteins is in fact the primary pathway whereby therapeutically-useful effects are achieved. Here, a review is given of the known instances of interaction of cisplatin and related compounds with proteins and biologically relevant peptides, with emphasis on structural and reactivity aspects.

引用

页码：214 / 224

页数：11

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