The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis

被引：571

作者：

Huettemann, Maik ^{[1
]}

Pecina, Petr ^{[1
]}

Rainbolt, Matthew ^{[1
]}

Sanderson, Thomas H. ^{[4
]}

Kagan, Valerian E. ^{[2
,3
]}

Samavati, Lobelia ^{[1
]}

Doan, Jeffrey W. ^{[1
]}

Lee, Icksoo ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA

[2] Univ Pittsburgh, Ctr Free Rad & Antioxidant Hlth, Pittsburgh, PA 15219 USA

[3] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA 15219 USA

[4] Wayne State Univ, Dept Emergency Med, Sch Med, Detroit, MI 48201 USA

来源：

MITOCHONDRION | 2011年 / 11卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Aging; Apoptosis; Cardiolipin; Cell signaling; Cytochrome c; Oxidative phosphorylation; Reactive oxygen species; AMYOTROPHIC-LATERAL-SCLEROSIS; MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION; ISCHEMIC NEURONAL INJURY; GLOBAL CEREBRAL-ISCHEMIA; STRESS-INDUCED APOPTOSIS; HIPPOCAMPAL CA1 NEURONS; TRANSGENIC MOUSE MODEL; NECROSIS-FACTOR-ALPHA; SPINAL-CORD-INJURY; IN-VIVO;

D O I：

10.1016/j.mito.2011.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy conditions, produces ROS with the co-factor p66(Shc), and oxidizes cardiolipin during apoptosis. The recent finding that Cytc is phosphorylated in vivo underpins a model for the pivotal role of Cytc regulation in making life and death decisions. An apoptotic sequence of events is proposed involving changes in Cytc phosphorylation, increased ROS via increased mitochondrial membrane potentials or the p66(Shc) pathway, and oxidation of cardiolipin by Cytc followed by its release from the mitochondria. Cytc regulation in respiration and cell death is discussed in a human disease context including neurodegenerative and cardiovascular diseases, cancer, and sepsis. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：369 / 381

页数：13

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