Effect of the p53 codon 72 and intron 3 polymorphisms on non-small cell lung cancer (NSCLC) prognosis

被引：18

作者：

Boldrini, Laura ^{[1
]}

Gisfredi, Silvia ^{[1
]}

Ursino, Silvia ^{[1
]}

Lucchi, Marco ^{[2
]}

Greco, Giordana ^{[1
]}

Mussi, Alfredo ^{[2
]}

Donati, Valentina ^{[1
]}

Fontanini, Gabriella ^{[1
]}

机构：

[1] Univ Pisa, Dept Surg, I-56126 Pisa, Italy

[2] Univ Pisa, Dept Cardiothorac Surg, I-56126 Pisa, Italy

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 02期

关键词：

TP53; gene; Arg72Pro polymorphism; intron; 3; polymorphism; NSCLC; prognosis;

D O I：

10.1080/07357900701788023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 42 polymorphisms have been identified in the TP53 gene. The polymorphic site of p53 at codon 72 in exon 4 and p53PIN3, a 16 bp insertion/duplication in intron 3, are the most studied. We tested p53PIN3 and the combined effect of the p53 codon72 and PIN3 polymorphisms on prognosis in 101 NSCLC cases. This study provides support for the prognostic effects of the multi-variant alleles from p53 exon 4 and intron 3, resulting in a significantly poorer prognosis in NSCLC. This approach highlights the value of examining multiple polymorphisms in genes to improve survival estimates.

引用

收藏

页码：168 / 172

页数：5

相关论文

共 23 条

[1] The codon 72 polymorphic variants of p53 have markedly different apoptotic potential [J].

Dumont, P ;

Leu, JIJ ;

Della Pietra, AC ;

George, DL ;

Murphy, M .

NATURE GENETICS, 2003, 33 (03) :357-365

[2] A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA [J].

Gemignani, F ;

Moreno, V ;

Landi, S ;

Moullan, N ;

Chabrier, A ;

Gutiérrez-Enríquez, S ;

Hall, J ;

Guino, E ;

Peinado, MA ;

Capella, G ;

Canzian, F .

ONCOGENE, 2004, 23 (10) :1954-1956

[3] The p53 codon 72 Proline allele is associated with p53 gene mutations in non-small cell lung cancer [J].

Hu, YC ;

McDermott, MP ;

Ahrendt, SA .

CLINICAL CANCER RESEARCH, 2005, 11 (07) :2502-2509

[4]

LAZAR V, 1993, ONCOGENE, V8, P1703

[5] TP53 polymorphisms and lung cancer risk:: a systematic review and meta-analysis [J].

Matakidou, A ;

Eisen, T ;

Houlston, RS .

MUTAGENESIS, 2003, 18 (04) :377-385

[6]

MATAKIDOU A, 2007, IN PRESS LUND CANC

[7] PRIMARY STRUCTURE POLYMORPHISM AT AMINO-ACID RESIDUE-72 OF HUMAN-P53 [J].

MATLASHEWSKI, GJ ;

TUCK, S ;

PIM, D ;

LAMB, P ;

SCHNEIDER, J ;

CRAWFORD, LV .

MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (02) :961-963

[8] The IARC TP53 database: New Online mutation analysis and recommendations to users [J].

Olivier, M ;

Eeles, R ;

Hollstein, M ;

Khan, MA ;

Harris, CC ;

Hainaut, P .

HUMAN MUTATION, 2002, 19 (06) :607-614

[9] Associations between common polymorphisms in TP53 and p21WAF1/Cip1 and phenotypic features of breast cancer [J].

Powell, BL ;

van Staveren, IL ;

Roosken, P ;

Grieu, F ;

Berns, EMJJ ;

Iacopetta, B .

CARCINOGENESIS, 2002, 23 (02) :311-315

[10] P53-BASED BLOOD-TEST FOR P53PIN3 AND RISK FOR SPORADIC OVARIAN-CANCER [J].

RUNNEBAUM, IB ;

TONG, XW ;

KONIG, R ;

HONG, Z ;

KORNER, K ;

ATKINSON, EN ;

KREIENBERG, R ;

KIEBACK, DG .

LANCET, 1995, 345 (8955) :994-994